Mussels’ sticky feet lead to applications

Ornes, Stephen

doi:10.1073/pnas.1317104110

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…This high bonding strength of the Notaden glue has already caused great interest for practical applications in the industrial 3 , 9 and medical sectors 10 , 11 . This is a similar situation as has been given for the byssal system of mussels 12 , 13 or gecko nanotopography 14 .…”

Section: Introductionsupporting

confidence: 78%

Chemical characterization of the adhesive secretions of the salamander Plethodon shermani (Caudata, Plethodontidae)

Byern

Grunwald

Kosok

et al. 2017

Sci Rep

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Salamanders have developed a wide variety of antipredator mechanisms, including tail autotomy, colour patterns, and noxious skin secretions. As an addition to these tactics, the red-legged salamander (Plethodon shermani) uses adhesive secretions as part of its defensive strategy. The high bonding strength, the fast-curing nature, and the composition of the biobased materials makes salamander adhesives interesting for practical applications in the medical sector. To understand the adhesive secretions of P. shermani, its components were chemically analysed by energy dispersive X-ray spectroscopy (EDX), inductively coupled plasma mass spectrometry (ICP-MS), amino acid analysis, and spectroscopy (ATR-IR, Raman). In addition, proteins were separated by gel-electrophoresis and selected spots were characterised by peptide mass fingerprinting. The salamander secretion contains a high amount of water and predominantly proteins (around 77% in the dry stage). The gel-electrophoresis and peptide mass fingerprint analyses revealed a de novo set of peptides/proteins, largely with a pI between 5.0 and 8.0 and a molecular mass distribution between 10 and 170 kDa. Only low homologies with other proteins present in known databases could be identified. The results indicate that the secretions of the salamander Plethodon clearly differ chemically from those shown for other glue-producing terrestrial or marine species and thus represent a unique glue system.

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Section: Introductionsupporting

confidence: 78%

Chemical characterization of the adhesive secretions of the salamander Plethodon shermani (Caudata, Plethodontidae)

Byern

Grunwald

Kosok

et al. 2017

Sci Rep

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“…One good example is the dopamine-based tissue adhesives inspired by the marine mussels that have the capacity to adhere to wet or moisture surfaces, which is an essential requirement for any adhesives to be used in the eld of surgery and medicine. [35][36][37][38][39][40][41] Herein, we make a concise review of tissue adhesives with unique chemical properties and their recent applications and developments. Specically, mussel-inspired dopamine-based tissue adhesives for biomedical application will be the focus of discussion in terms of their key properties, mechanism and applications.…”

Section: Introductionmentioning

confidence: 99%

Mussel-inspired hydrogel tissue adhesives for wound closure

2017

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“…DOPA contains a chemical group called catechol (3,4-dihydroxyphenyl), made from a benzene ring bearing two adjacent hydroxyl (-OH) groups, as shown in figure 3. Further studies on catecholic amino acid revealed that the hydroxyl groups of the catechol form chemical bonds with rocks and other substrates that help to stick the mussel in place (Ornes, 2013). Although DOPA-mediated wet adhesion is strong and versatile on different surfaces, it has a troubling tendency to readily oxidize to Dopaquinone and formation of Dopaquinone diminishes adhesion of Mfps to surfaces by at least 80-95%.…”

Section: Introductionmentioning

confidence: 99%

Propiedades Adhesivas Húmedas de la Proteína del Pie de Mejillones Verdes Asiático (Perna viridis) Pvfp-5: Una Base Adhesiva Subacuática

2018

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Los mejillones verdes asiáticos (Perna viridis) son bivalvos que se adhieren firmemente a las rocas en las costas intermareales golpeadas por las olas a través de una secreción proteica. Los mejillones de P. viridis siguen una secreción de proteínas adhesivas regulada en el tiempo, donde la proteína del pie-5 de P. viridis (Pvfp-5) fue identificada como la primera proteína que se secreta durante la formación de la placa adhesiva. El alto contenido de aminoácido catecólico 3,4-dihidroxi-L-fenilalanina (DOPA) (~11% en moles) y cisteína (CYS) (~15% en moles) en Pvfp-5 y su localización cerca de la interfaz placa-sustrato provocó la especulación de que la proteína de vanguardia Pvfp-5 desempeña un papel clave como imprimación adhesiva en la adhesión bajo el agua de los mejillones de P. viridis. El aparato de fuerza de superficie (SFA) se usó para probar las propiedades adhesivas de Pvfp-5 a escala nanométrica, donde se investigó la adhesión húmeda dependiente del pH y la actividad antioxidante de Pvfp-5 purificado y extraído. El estudio reveló que Pvfp-5 con su alto contenido de DOPA y CYS mantiene la adhesión incluso a un pH más alto al superar la oxidación espontánea de DOPA a quinona. Los resultados de SFA son consistentes con la función aparente de que Pvfp-5 actúa como imprimación adhesiva, superando las fuerzas de hidratación repulsivas al desplazar el agua unida a la superficie y generando una adhesión superficial fuerte y duradera. Nuestros hallazgos revelan conocimientos a escala molecular que deberían ser relevantes e impactar en las ciencias de los materiales al desarrollo de la nueva generación de adhesivos, recubrimientos y pegamentos resistentes a la humedad para aplicaciones biomédicas, terapéuticas y antiincrustantes.

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Mussels’ sticky feet lead to applications

Cited by 5 publications

References 11 publications

Chemical characterization of the adhesive secretions of the salamander Plethodon shermani (Caudata, Plethodontidae)

Chemical characterization of the adhesive secretions of the salamander Plethodon shermani (Caudata, Plethodontidae)

Mussel-inspired hydrogel tissue adhesives for wound closure

Propiedades Adhesivas Húmedas de la Proteína del Pie de Mejillones Verdes Asiático (Perna viridis) Pvfp-5: Una Base Adhesiva Subacuática

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