Mustard gas scarring with specific pigmentary, trophic and vascular charactristics (case report, 16-year post-exposure)

Emadi, Seyed Naser; Hosseini-khalili, Alireza; Soroush, Mohammad Reza; Davoodi, Seyed Masoud; Aghamiri, Seyed Samad

doi:10.1016/j.ecoenv.2007.01.003

Cited by 19 publications

(10 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have been reported that eczema, xerosis, cherry angioma, hyperpigmentation and seborrheic dermatitis are the long term skin complications in the SM exposed subjects [16,30,31]. In the dermatologic setting GM-CSF has been reported to exhibit efficacy as a wound-healing agent for ulcerated skin by promoting the proliferation of keratinocytes [32].…”

Section: Discussionmentioning

confidence: 99%

Serum levels of GM-CSF 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Amiri

Ghazanfari

Yaraee

et al. 2009

International Immunopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Serum levels of GM-CSF 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Amiri

Ghazanfari

Yaraee

et al. 2009

International Immunopharmacology

View full text Add to dashboard Cite

“…The chronic effects on the skin were documented in many papers describing injuries of Iran‐Iraq War victims. The most common complaint of the patients with chronic lesions was persistent pruritus (70–90%) . Additional frequent late pathologies included dry skin (xerosis), burning sensation, pain, and desquamation .…”

mentioning

confidence: 99%

“…The most common complaint of the patients with chronic lesions was persistent pruritus (70–90%) . Additional frequent late pathologies included dry skin (xerosis), burning sensation, pain, and desquamation . Also the development of scarring may occur due to uncontrolled fibroblastic activity .…”

mentioning

confidence: 99%

“…Many victims reported hyperpigmentation (20–55%), and some exhibited hypopigmentation (5–25%). It is suggested that hypopigmentation develops more frequently after exposure to higher doses . In addition, it is suggested, that the affected areas are more sensitive to subsequent mechanical injury and to developing chronic eczema, dermatitis, cherry angioma, urticaria, atrophy, and hair loss .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Characterization of acute and long‐term pathologies of superficial and deep dermal sulfur mustard skin lesions in the hairless guinea pig model

Dachir

Cohen

Kamus-Elimeleh

et al. 2012

Wound Repair Regeneration

View full text Add to dashboard Cite

Sulfur mustard induces severe acute and prolonged damage to the skin and only partially effective treatments are available. We have previously validated the use of hairless guinea pigs as an experimental model for skin lesions. The present study aimed to characterize a model of a deep dermal lesion and to compare it with the previously described superficial lesion. Clinical evaluation of the lesions was conducted using reflectance colorimetry, trans-epidermal water loss and wound area measurements. Prostaglandin E(2) content, matrix metalloproteinase-2 and 9 activity, and histopathology were conducted up to 4 weeks post-exposure. Sulfur mustard skin injury, including erythema and edema, impairment of skin barrier and wounds developed in a dose-dependent manner. Prostaglandin E(2) content and matrix metalloproteinase-2 and 9 activities were elevated during the wound development and the healing process. Histological evaluation revealed severe damage to the epidermis and deep dermis and vesications. At 4 weeks postexposure, healing was not completed: significantly impaired stratum corneum, absence of hair follicles, and epidermal hyperplasia were observed. These results confirm the use of the superficial and deep dermal skin injuries in the hairless guinea pigs as suitable models that can be utilized for the investigation of the pathological processes of acute as well as long-term injuries. These models will be further used to develop treatments to improve the healing process and prevent skin damage and long-term effects.

show abstract

“…3). 18,19 Depigmented patches were noted on the external urethral orifice and glans of the penis, which are indications of high‐dose SM exposure, with consequent destruction of melanocytes, sclerodermal changes, and fibrotic obstruction (Fig. 2).…”

Section: Discussionmentioning

confidence: 99%

External urethral stenosis: a latent effect of sulfur mustard two decades post‐exposure

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

Mustard gas scarring with specific pigmentary, trophic and vascular charactristics (case report, 16-year post-exposure)

Cited by 19 publications

References 5 publications

Serum levels of GM-CSF 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Serum levels of GM-CSF 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Characterization of acute and long‐term pathologies of superficial and deep dermal sulfur mustard skin lesions in the hairless guinea pig model

External urethral stenosis: a latent effect of sulfur mustard two decades post‐exposure

Contact Info

Product

Resources

About