Mutagene und karzinogene Wirkungen von Suchtstoffen

Obe, G.; Brodmann, R.; Fleischer, R.; Engeln, H.; Göbel, D; Herha, J.

doi:10.1007/978-3-642-82542-2_3

Suchtproblematik

1985

DOI: 10.1007/978-3-642-82542-2_3

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Mutagene und karzinogene Wirkungen von Suchtstoffen

G. Obe¹,

R. Brodmann²,

R. Fleischer³

et al.

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Cited by 2 publications

References 33 publications

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Chromosomal Aberrations in Peripheral Lymphocytes of Abstinent Alcoholics

Gattás

Saldanha²

1997

Alcoholism Clin & Exp Res

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The frequency of structural and/or numerical chromosomal aberrations in human metaphasic cells of lymphocyte cultures from abstinent alcoholics who were abstinent for 1 month up to 32 years was compared with those from controls not selected for alcohol consumption. Cytogenetic analyses revealed a significant increase of the frequencies of cells with structural aberrations in the abstinent alcoholics (7.1%), compared with controls (2.4%). The frequency of numerical aberrations showed a significant regression on ages in abstinent alcoholics and controls. These results suggest specific action of chronic alcohol consumption impairing biological repair with aging. The increased frequency of chromosome-type aberrations associated with alcohol consumption, even after long withdrawal, could be due to an action of ethanol or its metabolites on primordial leukopoietic cells.

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Chromosomal Aberrations in Peripheral Lymphocytes of Abstinent Alcoholics

Gattás

Saldanha²

1997

Alcoholism Clin & Exp Res

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A Follow‐Up Study on Chromosomal Aberrations in Lymphocytes of Alcoholics During Early, Medium, and Long‐Term Abstinence

Hüttner

Matthies

Nikolova

et al. 1999

Alcoholism Clin & Exp Res

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The frequencies of structural chromosomal aberrations were analyzed in peripheral blood lymphocytes of 31 chronic alcoholics at the beginning of an intensive outpatient treatment program at a neuropsychiatric clinic and were compared with 31 controls matched for gender, age, smoking habits, and nondrinkers. A statistically significant difference was observed in the level of chromosomal aberrations in somatic cells from alcoholics when compared with controls (3.01% vs. 1.28%, p < or = 0.001). A follow-up study was carried out for a subset of the patients after 3 months (8 subjects) and 12 months (14 subjects) of controlled abstinence. A statistically significant increase in the mean frequency of cells with aberrations was observed in the group of 14 subjects reinvestigated after 12 months of abstinence when compared with the mean value of the first blood samples immediately after hospitalization (4.61% vs. 3.01%; p < or = 0.001). An excessive increase in cigarette consumption during alcohol abstinence, reflected by a dramatic elevation of CO-hemoglobin levels, may, at least in part, account for this finding. In conclusion, chronic alcoholism leads to genotoxic effects that, instead of recovering after 1 year of alcohol abstinence, are even enhanced, most likely due to the "shift in addictive behavior."

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Mutagene und karzinogene Wirkungen von Suchtstoffen

Cited by 2 publications

References 33 publications

Chromosomal Aberrations in Peripheral Lymphocytes of Abstinent Alcoholics

Chromosomal Aberrations in Peripheral Lymphocytes of Abstinent Alcoholics

A Follow‐Up Study on Chromosomal Aberrations in Lymphocytes of Alcoholics During Early, Medium, and Long‐Term Abstinence

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