Mutagenic action of aromatic epoxy resins

Bisphenol-A induces cellular transformation, aneuploidy and DNA adduct formation in cultured Syrian hamster embryo cells

“…BP-A is not mutagenic to Salmonella typhimurium TA 1535 or TA 100 with or without the addition of rat liver microsomal extract (Andersen et al, 1978) and fails to cause sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells (Ivett et al, 1989). Atkinson and Roy (1995a) demonstrated that BP-A is oxidized to bisphenol o-quinone in the presence of an activation system and that the chemical reaction of DNA with bisphenol o-quinone produces adducts.…”

Authors` response to WF Diller`s Letter to the Editor – Scand J Work Environ Health 1981;7:237–238

“…Another example is the one of aromatic epoxy resins. In 1978 they were shown to be mutagenic in the Ames test (1). As earlier animal tests had shown that they were not carcinogenic, the Ames test results could also in this case be called "false positive."…”

Potential carcinogenic and mutagenic industrial chemicals. I. Alkylating agents

“…The consumption of epoxy resins during 1973 worldwide was 190,000 metric tons-an almost twofold increase over a period of 10 yr (Sorin, 1974). Workers may be exposed to the resins during their manufacture by skin contact or by inhalation of air contaminated with particles of resin (Andersen et al, 1978). Epoxy resins are diepoxides, and a number of bifunctional alkylating agents are known to be mutagenic (McCann et al, 1975a;Sram et al, 1976;Wade et al, , 1979.…”