Mutagenic and antimutagenic potential of the medicinal plants <i>M. laevigata</i> and <i> C. xanthocarpa</i>

Fernandes, Jennifer; Vargas, Vera Maria Ferrão

doi:10.1002/ptr.1058

Cited by 31 publications

(23 citation statements)

References 14 publications

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“…The mutagenic activity of the extracts of C. xanthocarpa was evaluated by Fernandes and Vargas (2003) for Salmonella/microssome test. The authors reported that C. xanthocarpa showed frameshift (TA97 strain) signs of mutagenic activity without exogenous metabolism (S9 fraction), and these results were attributed to different active substances acting on the nDNA.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic effects ofCampomanesia xanthocarpaextracts onAllium cepavegetal system

Pastori

Flôres

Boligon

et al. 2013

Pharmaceutical Biology

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Context: Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known in Brazil as guabiroba, is a plant used as antidiarrheic, anti-inflammatory and antirheumatic agents, and in stomach and hepatic disorders. Objective: The antiproliferative and genotoxic effects of aqueous extracts and essential oil of C. xanthocarpa were evaluated. Materials and methods: Cytotoxicity and genotoxicity of the aqueous extracts (6 and 30 mg/mL) and essential oil (0.25%, v/v) obtained from leaves of C. xanthocarpa were evaluated using the Allium cepa L. (Amaryllidaceae) assay. Mitotic index was calculated as the percentage of dividing cells of total cells observed; chromosome abnormalities were observed and counted during cell division. Additionally, the composition of the essential oil and the quantification of the main compounds of the extracts were determined by gas chromatography/mass spectrometry and high performance liquid chromatography coupled with diode array detector, respectively. Results and discussion: Aqueous extracts (6 and 30 mg/mL) led to a reduction of 67.7% and 34.1% of the mitotic index, respectively, whereas the treatment with essential oil caused a 48.2% reduction in the mitotic index, when compared with negative control. Chromosomal mutations were observed and included anaphase bridges, delay chromosome, break chromosome, as well as metaphase with disorganized chromosomal and binuclear cells. The main compounds of the essential oil were b-caryophyllene (8.87%), viridiflorol (6.40%), spathulenol (5.16%), d-cadinene (4.92%), linalool (4.46%) and a-cadinol (4.25%). Gallic acid (3.19%), chlorogenic acid (1.04%), quercetin (2.97%) and rutin (4.82%) were identified in an aqueous extract (30 mg/mL). Conclusion: Our results demonstrated that genotoxic and antiproliferative activities are present in C. xanthocarpa infusions using the in vivo onion root-tip cell test.

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Section: Discussionmentioning

confidence: 99%

Genotoxic effects ofCampomanesia xanthocarpaextracts onAllium cepavegetal system

Pastori

Flôres

Boligon

et al. 2013

Pharmaceutical Biology

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“…Despite its popular use, there is scant pharmacological information available on this plant. Markman et al (2004) described the anti-ulcerogenic activity of the alcoholic extract and Fernandes and Vargas (2003) demonstrated mutagenic and anti-mutagenic potential. The chronic treatment of obese rats with the infusion of the leaves of C. xanthocarpa led to a significant decrease in body mass, as well as a reduction in glycemia (Biavatti et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

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The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocininduced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed. O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/ kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.Unitermos: Campomanesia xanthocarpa/farmacognosia. Diabete Melito/estudo experimental. Planta hipoglicemiante. Carboidratos/metabolismo. Lipídeos/metabolismo.

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“…Previous study using aqueous leaf extract in Salmonella/microsome test demonstrated the mutagenic potential of Campomanesia xanthocarpa in a dose-dependent manner, in TA97 strain (frameshift mutation) without metabolic activation (Fernandes and Vargas, 2003).…”

Section: Discussionmentioning

confidence: 98%

“…Doses were selected based on doses reported in studies by Fernandes and Vargas (2003) and de Souza et al (2014).…”

Section: Adamantium Hydroethanolic Extractmentioning

confidence: 99%

Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism

Martello¹,

David²,

Matuo

et al. 2016

Genet. Mol. Res.

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Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa

Cited by 31 publications

References 14 publications

Genotoxic effects ofCampomanesia xanthocarpaextracts onAllium cepavegetal system

Genotoxic effects ofCampomanesia xanthocarpaextracts onAllium cepavegetal system

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism

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