Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives

Abstract

Nowadays, there are increasing numbers of studies about synthetic chemicals according to the supply demands of bioactive chemicals. The current study aims to investigate genotoxic potential of bioactive synthetic pyridine compounds, phenyl-3-pyridinylmethanone (1), p-tolyl-3-pyridinylmethanone (2), and 4-methoxyphenyl-3-pyridinylmethanone (3), using Ames/Salmonella and Escherichia coli WP2 bacterial reversion mutagenicity test systems. The mutant bacterial tester strains sodium azide-sensitive Salmonella typhimurium TA1535, 9-aminoacridine-sensitive S. typhimurium TA1537, and N-methyl-N'-nitro-N-nitrosoguanidine-sensitive E. coli WP2uvrA were used to detect the mutagenic potential of the test compounds. The results indicated that none of the test substances showed significant mutagenic activity on S. typhimurium TA1535, TA1537, and E. coli WP2uvrA bacterial strains up to 1 µg/plate concentrations.

Preliminary Safety Assessment of New Azinesulfonamide Analogs of Aripiprazole using Prokaryotic Models

“…20 As regards the Ames test, two compounds concentrations were employed, namely the one used in the Vibrio harveyi assay and the higher one commonly used in the assay. 10,21,22 Bacterial strains Four Vibrio harveyi strains were used in the experiments: wild-type BB7 and genetically modified strains: BB7M, BB7X and BB7XM. [14][15][16] These strains were kindly provided by Prof. G. Węgrzyn (University of Gdańsk, Poland).…”