Mutagenic effect of aromatic epoxy resins (reply)

HETA 98-0011-2801, Woodbridge Corporation, Brodhead, Wisconsin.

“…TDI was also found to have a dose-dependent mutagenic effect on two strains of Salmonella typhimurium in the presence of a metabolic activator (S-9 liver fractions from rats or hamsters treated with Aroclor 254). 44 Based on these animal and in vitro studies, NIOSH concluded that sufficient evidence exists to classify TDI as a potential occupational carcinogen, and recommends that exposures be reduced to the lowest feasible concentration (LFC). 45 It is important to note that no epidemiologic data exist linking TDI exposure to elevated cancer rates in exposed workers.…”

HETA 98-0347-2758, Lockheed Martin Aeronautical Systems, Marietta, Georgia.

“…Also, commercial-grade TDI was found to have a dose-dependent mutagenic effect on two strains of Salmonella typhimurium in the presence of a metabolic activator (S-9 liver fractions from rats or hamsters treated with Aroclor 254). 43 Based on these animal and in vitro studies, the National Institute for Occupational Safety and Health (NIOSH) concluded that sufficient evidence exists to classify TDI as a potential occupational carcinogen. 44 It is important to note that no epidemiologic data exists linking TDI exposure to elevated cancer rates in exposed workers.…”

HETA 94-0312-2512, Square D Company, Oshkosh, Wisconsin.

“…Commercial-grade TDI was found to have a dose-dependent mutagenic effect on two strains of Salmonella typhimurium in the presence of a metabolic activator (S-9 liver fractions from rats or hamsters treated with Aroclor 254). 44 Based on these animal and in vitro studies, NIOSH concluded that sufficient evidence exists to classify TDI as a potential occupational carcinogen. 45 Considering this, NIOSH recommends that occupational exposures to TDI be reduced to the lowest feasible concentrations.…”