Mutagenic heterocyclic aromatic amines (HAAs) in ‘processed food flavour’ samples

Evaluation of different liquid chromatography–electrospray mass spectrometry systems for the analysis of heterocyclic amines

“…In the last few years, several laboratories have worked with atmospheric pressure ionisation sources for the determination of HAs by liquid chromatography-mass spectrometry (LC-MS), using different analysers. Among them, single and triple quadrupole in selected ion monitoring (SIM) acquisition mode have been the most frequently used [20][21][22][23][24][25][26][27][28][29]. Nevertheless, in the last few years, the selectivity provided by the triple quadrupole analyser working in multiple reaction monitoring (MRM) mode has allowed limits of detection to be decreased [30][31][32] in complex samples.…”

Evaluation of reversed-phase columns for the analysis of heterocyclic aromatic amines by liquid chromatography—electrospray mass spectrometry

“…In the last years, liquid chromatography-mass spectrometry (LC-MS) has shown to be one of the most powerful analytical techniques because of the capacity of separation of nonvolatile, thermolabile and polar compounds provided by LC and also because of the selectivity and sensitivity of MS [16][17][18][19][20][21][22][23].…”

Tumor Suppressor P53 Gene Mutations Pattern Induced by Repeated Fried Palm Oil in Rats

“…Our results are in an agreement with that of Mariam et al (2010) which indicated that fried oil food has a mutagenic effect on the genomic materials of male mice. This mutagenic effect may be due to the formation of oxidative compounds of lipidperoxid or Heterocyclic Aromatic Amines (HAAs), that have been found to be mutagenic or carcinogenic (Hamilton et al, 1997;Starvic et al, 1997;Raloff, 1999;Coultate, 2009;Bou et al, 2008). Lipidperoxid compounds may be associated with generation of free radicals causing DNA fragmentation or DNA mutation (Lampe, 1999;Coultate, 2009;Nicolle et al, 2003;Bou et al, 2008).…”