Mutagenic potential of acute exposure to organophosphorus and organochlorine compounds

Vijayaraghavan, Meenakshi; Nagarajan, B.

doi:10.1016/0165-1218(94)90126-0

Cited by 48 publications

(17 citation statements)

References 14 publications

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“…Evidence of clastogenicity and mutagenicity of methyl and ethyl parathion have been reported in some studies and includes sister chromatid exchange in cell lines [Chen et al, 1981] and human chromosome aberrations [Kiraly et al, 1979;Van Bao et al, 1974;Vijayaraghavan and Nagarajan, 1994]. However, other studies have found no such effects in mice [Degraeve and Moutschen, 1984] or in humans [De Cassia Stocco et al, 1982].…”

Section: Introductionmentioning

confidence: 91%

Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method

et al. 1999

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Section: Introductionmentioning

confidence: 91%

Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method

et al. 1999

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“…It can induce chromosome aberrations and micronuclei due to its clastrogenic potential [Vijayaraghavan and Nagarajan, 1994]. Published results about the mutagenicity of methyl parathion in the Ames Salmonella/mammalian microsome test are ambiguous [Vijayaraghavan and Nagarajan, 1994;Wagner et al, 2003;Hreljac and Filipic, 2009]. Wagner et al [2003] reported mutagenicity of methyl parathion in the strain YG1024, which is a derivate of the strain TA 98 that overproduce the O-AT.…”

Section: Resultsmentioning

confidence: 97%

“…Beside its neurotoxic mode of action, there is already some evidence that methyl parathion has a mutagenic potential as well. It can induce chromosome aberrations and micronuclei due to its clastrogenic potential [Vijayaraghavan and Nagarajan, 1994]. Published results about the mutagenicity of methyl parathion in the Ames Salmonella/mammalian microsome test are ambiguous [Vijayaraghavan and Nagarajan, 1994;Wagner et al, 2003;Hreljac and Filipic, 2009].…”

Section: Resultsmentioning

confidence: 98%

Identification of mutagens in freshwater sediments by the Ames‐fluctuation assay using nitroreductase and acetyltransferase overproducing test strains

Reifferscheid

Buchinger

Cao

et al. 2010

Environ and Mol Mutagen

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Extracts of sediments from an area of concern in the Elbe river basins (Spittelwasser creek) were analyzed with the Ames-fluctuation test and in parallel with gas chromatography/mass spectrometry for compound identification. The standard test strains TA 98 and TA 100 showed mutagenicity mainly in medium-polar fractions of the sediment extracts. PAHs contribute to the overall mutagenic potential of the sample. Especially, cyclopenta[c,d]pyrene that was previously not defined as a priority hazardous substance has to be considered as well. The addition of metabolically competent test strains, which overexpress nitroreductase and acetyltransferase (e.g., YG1041 and YG1042) to the test battery, increased significantly the sensitivity of the Ames test for medium polar to polar genotoxins. The increased mutagenicity that was found in these bacterial strains indicates the presence of nitroarenes and/or aromatic amines. In fact, a number of heterocyclic and nitrogen-substituted aromatic compounds were identified in the sediments of the Spittelwasser creek of which methyl parathion, 1-naphthylamine, and N-phenyl-2-naphthylamine are mutagenic.

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“…As for the genotoxic status of methyl parathion several workers have tried to evaluate its harmful effects on the genetic material of a variety of test organisms. For example, increased frequency of chromosomal aberrations, sister chromatid exchanges and the production of micronuclei was observed in mice, rat, Drosophila and human cell in culture (De Cassia et al, 1982, Grover andMalhi, 1985;Mathew et al, 1990;Rupa et al, 1989Rupa et al, , 1990Rupa et al, , 1991Kumar et al, 1993;Vijayaraghavan and Nagarajan, 1994;Das and John, 1999;Cakir and Sarikaya, 2005). In reference to these studies and the results obtained from present work, it could be concluded that both propoxur and methyl parathion are significantly genotoxic for the genome of a mosquito even at sublethal dose concentration of LC 20.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the mutagenic potential of propoxur and methyl parathion using polytene chromosomes of Anopheles stephensi

Chaudhry

Bhinder

Kumar

et al. 2012

JANS

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Abstract:The mutagenicity of two pesticides, propoxur and methyl parathion was evaluated by using polytene chromosomes of Anopheles stephensi. The results were based on the frequency of various structural aberrations encountered in the polytene chromosomes of the larvae treated with LC 20 of propoxur and methyl parathion separately. Propoxur induced a total of 67 aberrations as against 15 in the controls while methyl parathion induced 53 aberrations as against 13 in the controls. These aberrations were dominated by inversions, translocations, deletions, ectopic pairing, asynapses, breaks, fusions and induced puffing. The frequency of propoxur induced aberrations was highest in chromosome 3R followed by 2R, 3L, 2L and X-chromosome. Methyl parathion induced highest number of aberrations in 2R followed by 2L, 3R, 3L and X-chromosomes. This study suggests that larval polytene chromosomes are sensitive indicators of pesticide genotoxicity in which both propoxur and methyl parathion are significantly chromotoxic for the genome of a mosquito taken as an experimental insect.

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Mutagenic potential of acute exposure to organophosphorus and organochlorine compounds

Cited by 48 publications

References 14 publications

Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method

Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method

Identification of mutagens in freshwater sediments by the Ames‐fluctuation assay using nitroreductase and acetyltransferase overproducing test strains

Evaluation of the mutagenic potential of propoxur and methyl parathion using polytene chromosomes of Anopheles stephensi

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