Mutagenicity and genotoxicity assessment of the emerging mycotoxin Versicolorin A, an Aflatoxin B1 precursor

Al-Ayoubi, Carine; Alonso-Jauregui, María; Azqueta, Amaya; Vignard, Julien; Mirey, Gladys; Rocher, Ophélie; Oswald, Isabelle P.; Vettorazzi, Ariane; Soler, Laura

doi:10.1016/j.envpol.2023.122276

Cited by 6 publications

(1 citation statement)

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“…Mycotoxins are toxic secondary metabolites produced by fungal species that may contaminate food commodities. The Food and Agriculture Organization estimated global mycotoxin contamination of food crops at 25%, specifically due to aflatoxins (AFs). , AFs are the most toxic and carcinogenic compounds and produced through multiple enzymatic reactions. − In AF biosynthesis pathways, approximately 15 precursors, including norsoloric acid, versicolorin A (Ver A), and sterigmatocystin (ST), have been identified. − These precursors also contaminate food and agricultural products, posing a significant risk to human and animal health, which are necessary to be determined accurately. The development of detection methods for these AF precursors is mainly focused on Ver A and ST. − Wu et al established an in-tube solid-phase microextraction with high-performance liquid chromatography (HPLC) and successfully determined ST in rice samples .…”

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confidence: 99%

A Novel and Highly Efficient Microextraction Method for the Determination of Aflatoxin Precursor Averantin in Fatty Grain Samples

Li,

Sun,

Man

et al. 2024

J. Agric. Food Chem.

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Averantin (AVN) is an important aflatoxin biosynthetic precursor and has been listed in the screening range of mycotoxins. Herein, a novel ionic liquid-based one-, two-, and three-phase transition microextraction (IL-OTTPTME) method was combined with high-performance liquid chromatography for the extraction and determination of AVN in fatty grain samples. The formation of a homogeneous solution and three-phase system during the IL-OTTPTME process allowed both efficient extraction and coextracted lipid cleanup. Density functional theory calculations and distribution coefficient determination results demonstrated that AVN extraction by IL mainly occurred through hydrogen-bond and π−π interactions. Under optimized conditions, the LOD and LOQ of the proposed method were 0.5 and 1.5 ng/g, respectively. Finally, the method was used to determine AVN in several grains with different fat contents, achieving satisfactory relative recoveries (86.0−107.8%) and RSDs (1.2−6.2%, n = 3).

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