Mutagenicity and toxicity assessment of pulp mill effluent

Rao, S. S.; Burnison, B. Kent; Rokosh, D. A.; Taylor, C.M.

doi:10.1016/0045-6535(94)90030-2

Cited by 23 publications

(8 citation statements)

References 8 publications

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“…Nylund et al (1994) applied the SOS Chromotest and the Ames test (TA100, 3 9 ) to study kraft pulp spent liquors, and found the results of both assays to be similar. In a recent study of whole and fractionated bleached kraft mill effluent, Rao et al (1994) reported positive SOS Chromotest responses in XAD/NaOH extracts and in the original unfiltered effluent. This last study also showed some agreement between E. coli PQ37 and Salmonella strain TA100.…”

Section: Genotoxicity Of Whole Effluentsmentioning

confidence: 95%

Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

Legault

Blaise

Trottier

et al. 1996

Environ. Toxicol. Water Qual.

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Section: Genotoxicity Of Whole Effluentsmentioning

confidence: 95%

Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

Legault

Blaise

Trottier

et al. 1996

Environ. Toxicol. Water Qual.

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“…However, fewer researchers Metcalfe et al, . 1985;Rao et al, 1994;White et al, 1996a, b have Ž . attempted to investigate the geno toxicity of particlebound HOCs in industrial andror municipal wastewaters by solvent extraction.…”

Section: Genotoxicity Of Particulate-bound Hydrophobic Organic Compoundsmentioning

confidence: 99%

“…There is a great variety of extraction᎐ concentration procedures that are used to fractionate effluents and to perform biological testing including among others microbial, algal, and invertebrate bio-Ž monitoring schemes Walsh and Garnas, 1983;Wells et . al., 1990;Houk, 1992;Rao et al, 1994 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of toxicity and genotoxicity of hydrophobic organic compounds in wastewater

Pardos¹,

Blaise²

1999

Environ. Toxicol.

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This review highlights and discusses current state of the art and limitations in evaluation and assessment of potential (geno)toxic impact of particle‐bound hydrophobic organic compounds (HOCs) in wastewaters on receiving ecosystems. Despite extensive work on whole effluent toxicity testing and concomitant development of protocols for identifying chemical toxicants, little has been done to develop procedures and protocols to identify (geno)toxicity of the particle phase from industrial or municipal wastewaters. Some studies, however, have shown that particulate matter is of considerable importance in the delivery of genotoxins to receiving waters. Further, it has been suggested that such particle‐bound HOCs deposited in receiving waters often result in long‐term environmental impact. As a consequence, particle‐bound HOCs (geno)toxins should be recognized as an important potential hazard. The sparsity of work leads to suggestion of further research to improve understanding of the contribution of these particle‐bound pollutants from liquid wastes and their specific role in aquatic ecosystems. ©1999 John Wiley & Sons, Inc. Environ Toxicol 14: 241–247, 1999

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“…The Ames Salmonella Microsomal Mutagenicity test was carried out using S. typhimrrriirm TA-I00 without exogenous activation (S9). Filtered effluent sample (c0.2 pm) and the DEAE filtrate were tested for mutagenicity using the fluctuation assay procedure (Rao et al, 1994) at doses of 12.5-75% of the reaction mixture. Methanol extract of the DEAE effluent concentrate was assayed for mutagenicity using the Ames plate incorporation procedure (Maron and Ames, 1983) at doses of 50-500 pL per plate.…”

Section: Ames Mutagenicity Testmentioning

confidence: 99%

“…(1990) demonstrated that the Ames mutagenic materials in effluent acted as promoters of aflatoxin E l using fish bioassays. Rao et al (1994) have recently used the Ames test to shows that the majority of mutagenic substances in filtered pulp mill effluent were recoverable in certain effluent fractions (XAD-4 and XAD-8) using sodium hydroxide or methanol elution. These mutagenic materials in pulp mill effluent were predominantly direct acting mutagens, relatively polar and possibly organic acids.…”

Section: Introductionmentioning

confidence: 99%

Assessment of genotoxic potential of pulp mill effluent and an effluent fraction using ames mutagenicity and Umu‐C genotoxicity assays

Rao

Burnison

Efler

et al. 1995

Environ. Toxicol. Water Qual.

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The Ames Mutagenicity Fluctuation and the Umu‐C genotoxicity bioassays were applied to assess the genotoxic potential in pulp mill effluents and their fractions. Mutagenicity was measured in the filtered effluents and the methanol extract of the diethyl‐amino‐ethyl cellulose. (DEAE) adsorbed materials by the Ames Fluctuation assay. The Umu‐C genotoxicity assay was applied only to the methanol extract of the DEAE adsorbed materials. Data indicate that the majority of the mutagenic substances from the filtered effluent were adsorbed by the DEAE cellulose and were effectively recovered with methanol. Approximately 1/3n to 1/6 of the materials in the effluent passed through the DEAE cellulose. The responses of the test organisms to genotoxic substances in the methanol extract fractions were comparable, suggesting that either one of these two bioassays could be used in screening pulp and paper effluents for genotoxicity. © by John Wiley & Sons, Inc.

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Mutagenicity and toxicity assessment of pulp mill effluent

Cited by 23 publications

References 8 publications

Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

Assessment of toxicity and genotoxicity of hydrophobic organic compounds in wastewater

Assessment of genotoxic potential of pulp mill effluent and an effluent fraction using ames mutagenicity and Umu‐C genotoxicity assays

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