Mutagenicity, carcinogenicity and teratogenicity of lithium compounds

Léonard, A.; Hantson, P.; Gerber, G. B.

doi:10.1016/0165-1110(95)90007-1

Cited by 49 publications

(23 citation statements)

References 51 publications

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“…The highest uptake of Li was reported for plant species growing on solonetz and solonchak soils or other soils having increased contents of alkali metals (Kabata-Pendias and Pendias 1992). Similar to plants, although Li does not have a known biological function and does not appear to be an essential element for life (Léonard et al 1995;Lenntech 2007), has been found in the blood and muscles of man and ruminant animals and in nearly all the organs of the human body (Schrauzer 2002). Some observations have suggested that low lithium intakes cause behavioral defects (Aral and Vecchio-Sadus 2008).…”

Section: Introductionmentioning

confidence: 96%

The occurrence of lithium in the environment of the Jordan Valley and its transfer into the food chain

Ammari

Al-Zu’bi

Abubaker

et al. 2010

Environ Geochem Health

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Lithium is found in trace amounts in all soils. It is also found in plants and in nearly all the organs of the human body. Low Li intake can cause behavioral defects. Thus, this study was conducted to investigate the concentration and distribution of water-soluble Li in soils of the Jordan Valley and its concentration in citrus trees and some important food crops in view of the significant implications of Li for human health. The concentration of soluble Li was measured in 180 soil samples collected at two depths (0-20 and 20-40 cm) whereas its content was determined in fully expanded leaves collected from citrus and different vegetable crops. Concentrations of soluble Li in soils vary from 0.95 to 1.04 mg l(-1) in topsoil and from 1.06 to 2.68 mg l(-1) in subsoil, while Li concentration in leaves ranged from 2 to 27 mg kg(-1) DM. Lithium concentrations in leaves of crops of the same family or different families vary with location in the valley; i.e., they decreased from north to south. It is concluded that soluble Li in soils and the plant family did not solely affect Li transfer in the food chain. In addition, soil EC, Ca, Mg, and Cl, which increased from north to south, might adversely affect plant Li uptake. The current study also showed that consuming 250-300 g FW of spinach day(-1) per person is recommended to provide consumers with their daily Li requirement necessary for significant health and societal benefits.

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Section: Introductionmentioning

confidence: 96%

The occurrence of lithium in the environment of the Jordan Valley and its transfer into the food chain

Ammari

Al-Zu’bi

Abubaker

et al. 2010

Environ Geochem Health

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“…The retardation factor (Rf) of the product is 0.66 while the Rf of the oleic acid is 0.87. Structural analysis based on FTIR spectrum (Figure 2) shows a disappearing absorption band at 3006 cm -1 from C-H sp 2 and an appearing band at 3279 cm -1 from the alcohol hydroxyl group (OH) which are indications that the hydroxylation was succeeded. The existence of hydroxyl carboxylic acid is shown at 3202 cm -1 (OH stretching), C=O carboxylic acid at 1697 cm -1 , methylene and methyl group at 1435 and 1375 cm -1 , respectively.…”

Section: Synthesismentioning

confidence: 99%

“…Furthermore, larval stages of aquatic organisms are particularly vulnerable to toxic substances contained in waste oil or lubricants in general. Toxins can accumulate in planktons and other tiny organisms at the bottom of the food chain and ultimately reach human beings as the contaminants move up the food chain [2]. However, Lithium does not have a known biological use and does not appear to be an essential element for life.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of some novel dioxolane compounds from Indonesian essential oils as potential biogreases

Wahyuningsih¹,

Kurniawan²

2017

AIP Conference Proceedings

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“…Lithium hypochlorite was not mutagenic in Salmonella and did not induce HGPRT mutations in CHO cells; although it did induce CA in vitro in CHO cells it did not induce w x them in rat bone marrow cells in vivo 173 . Leonard w x et al 174 , in a recent review of the mutagenicity of lithium compounds, concluded that they have no significant clastogenic activity and that mutagenic ( )activity is doubtful. Lithium has been shown to induce homeotic changes in developing zebrafish w x w x 175,176 and frogs 177-179 that are associated with alterations in gene expressions; and in frog embryos, lithium treatment is also associated with w x abnormal heart development 180 .…”

Section: ( ) 35 Lithium Cas 7439-93-2mentioning

confidence: 99%

Genetic toxicities of human teratogens

Bishop

Witt

Sloane

1997

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Birth defects cause a myriad of societal problems and place tremendous anguish on the affected individual and his or her family. Current estimates categorize about 3% of all newborn infants as having some form of birth defect or congenital anomaly. As more precise means of detecting subtle anomalies become available this estimate, no doubt, will increase. Even though birth defects have been observed in newborns throughout history, our knowledge about the causes and mechanisms through which these defects are manifested is limited. For example, it has been estimated that around 20% of all birth defects are due to gene mutations, 5-10% to chromosomal abnormalities, and another 5-l0% to exposure to a known x Resource for Clinicians TERIS , The John Hopkins University Press, Baltimore, 1994 , the mutagenic activity of environmental agents and drugs as a factor in teratogenesis has been given very little attention. Epigenetic activity has also been given only limited consideration as a mechanism for teratogenesis. As new molecular methods are developed for assessing processes associated with teratogenesis, especially those with a genetic or an epigenetic basis, additional environmental factors may be identified. These are especially important because they are potentially preventable. This paper Ž . examines the relationships between chemicals identified as human teratogens agents that cause birth defects and their mutagenic activity as evaluated in one or more of the established short-term bioassays currently used to measure such damage. Those agents lacking mutagenic activity but with published evidence that they may otherwise alter the expressions or regulate interactions of the genetic material, i.e. exhibit epigenetic activity, have likewise been identified. The information used in making these comparisons comes from the published literature as well as from unpublished data of the U.S. National Ž . Toxicology Program NTP . q 1997 Elsevier Science B.V.) Corresponding author. Tel.: q1-919-541-187; Fax: q1-919-541-4634; E-mail: bishop@niehs.nih.gov 0027-5107r97r$17.00 q 1997 Elsevier Science B.V. All rights reserved.Ž . PII S 0 0 2 7 -5 1 0 7 9 7 0 0 1 7 3 -5 ( ) J. B. Bishop et al.r Mutation Research 396 1997 9-43 10

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Mutagenicity, carcinogenicity and teratogenicity of lithium compounds

Cited by 49 publications

References 51 publications

The occurrence of lithium in the environment of the Jordan Valley and its transfer into the food chain

The occurrence of lithium in the environment of the Jordan Valley and its transfer into the food chain

Green synthesis of some novel dioxolane compounds from Indonesian essential oils as potential biogreases

Genetic toxicities of human teratogens

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