Mutagenicity of fume particles from metal arc welding on stainless steel in the Salmonella/microsome test

Maxild, Jette; Andersen, Margrethe; Kiel, Pauli; Stern, Richard M.

doi:10.1016/0027-5107(78)90190-2

Cited by 70 publications

(25 citation statements)

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“…The latter are generated by the vaporization and the oxidation of metals during the welding process [Yu et al, 2000 ;McNeilly et al, 2004]. Welding fumes from stainless steel are directly mutagenic in Escherichia coli and Salmonella typhimurium [Hedenstedt et al, 1977;Maxild et al, 1978]. Hansen and Stern [1985] reported that welding fumes transform BHK and SHE cells, and Baker et al [1986] found that they increase sister chromatid exchange (SCE) frequency in Chinese hamster lung (DON) cells.…”

Section: Introductionmentioning

confidence: 99%

Assessment of occupational exposure to welding fumes by inductively coupled plasma‐mass spectroscopy and by the alkaline Comet assay

Botta¹,

Iarmarcovai²,

Chaspoul³

et al. 2006

Environ and Mol Mutagen

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Welding fumes are classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer. In the current study, blood and urine concentrations of aluminum (Al), cadmium (Cd), cobalt (Co), chromium (Cr), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) were monitored by inductively coupled plasma-mass spectrometry (ICP-MS) in 30 welders and in 22 controls. In addition, DNA damage was examined in the lymphocytes of these subjects by the alkaline Comet assay. Two biological samples were taken from the welders at the beginning (BW) and at the end (EW) of a work week. In controls, collection of samples was limited to BW. Blood concentrations of Cd, Co, Cr, Ni, and Pb were higher in the welders than in the control group while higher concentrations of Al, Cd, Co, Cr, Ni, and Pb were detected in welder urines.There was no significant difference in the metal concentrations for the BW and EW welder samples. Increased levels of DNA damage were found in lymphocytes from welders as compared to the controls, and 20/30 welders had higher levels of DNA lesions in the EW than in the BW samples. Age had a significant effect on DNA damage in the control group. Spearman's rank correlation analysis indicated that there were positive correlations between blood concentrations of Al, Co, Ni, and Pb and the levels of DNA damage. A negative correlation was found between DNA damage and Mn in blood, while there was a positive correlation between urinary Mn concentration and DNA damage. These data indicate that occupational exposure to welding fumes increases DNA damage in lymphocytes. Environ. Mol. Mutagen. 47:284-295, 2006. V V C 2006 Wiley-Liss, Inc.

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Section: Introductionmentioning

confidence: 99%

Assessment of occupational exposure to welding fumes by inductively coupled plasma‐mass spectroscopy and by the alkaline Comet assay

Botta¹,

Iarmarcovai²,

Chaspoul³

et al. 2006

Environ and Mol Mutagen

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“…Fum es from stainless steel welding are mut agenic in bact eria tests (14) and cau se tran sformation in mammal ian cell transfo rmatio n assays (15). Fum es from mild steel welding have been found to be inactive in these test systems (15).…”

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Incidence of cancer among welders and other workers in a Norwegian shipyard.

Melkild¹,

Langård²,

Andersen³

et al. 1989

Scand J Work Environ Health

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ME LKIL D A, LA NGARD S, ANDERSEN A, ST RA Y T0N NESSEN IN. Incidence of ca ncer amo ng welders a nd ot her workers in a Norwegian shipya rd . Scand J Work Environ Health 1989; 15:387-394. The incidence of ca ncer a mo ng 4778 male ship yard workers, includi ng 783 mild steel welders, was investigat ed in a historical cohort study. Th e wor kers had been employed for a t least three months between I January 1946 a nd 31 March 1977. Th e incidence of cancer was observed from I January 1953 through 1986. Th e loss dur ing follow-up was o nly 0.9 OJ• • Th ere were 53 observed cases o f lung can cer in the whole coho rt versus 31.3 expected on the ba sis of the nat ional rates for men. T here was an increased incidence of lung cancer amo ng the welders, with seven observed cases versus 3.2 expected . Twenty-two cases of bladd er ca ncer were ob served versus 15.2 expected. Two mal ignan t mesoth eliomas had occurred (0.7 expected). Smoking was likely to be a confounder in the present study. Du e to con comit ant exposure to asbestos , the result s are inconclu sive concerni ng the possible relati on ship between exposure to welding fumes a nd lung ca ncer.

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“…Stainless steel is an alloy which contains mainly iron but also chromium (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and nickel (0.5-20 Ofo). The electrodes used contain about the same amount of chromium and nickel.…”

mentioning

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“…Fumes from mild steel welding have no mutagenic effect (5,11). Fume particles from stainless steel have also been shown to produce sister chromatid exchanges and chromosome aberrations in cultured Chinese hamster cells.…”

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A retrospective cohort study of mortality among stainless steel welders.

Sjögren¹

1980

Scand J Work Environ Health

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A retrospective cohort study of mortality among stainless steel welders. by Sjögren B Key terms: cohort study; mortality; pulmonary tumor; retrospective cohort study; retrospective study; stainless steel; stainless steel welder; welder; welding This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/6937824Scand j work environ health 6 (1980) 197-200 A retrospective cohort study of mortality among stainless steel welders by Bengt Sjogren, MD 1 SJOGREN B. A retrospective cohort study of mortality among stainless steel welders. Scand j work environ heaLth 6 (1980) 197-200. Hexavalent chromium particles are generated in the welding of stainless steel. These particles have manifested a mutagenic action in bacterial test systems and produced chromosome aberrations in cultured Chinese hamster cells. Welders who had welded stainless steel for more than 5 a during 1950-19<65 were selected for this study. According to an earlier survey the hexavalent chromium exposure of such welders was often above 50 flog/rna (calculated as Cr03). The cohort was followed un,til December 1977. The expected number of deaths was calculated from cause-, gender-, age-, and year-specific death rates of the general population in Sweden. In the cohort, consisting of 234 welders, the observed numbers of total deaths and deaths caused by tumors were the same as the expected numbers. However, three welders had died from pulmonary tumors in comparison to the expected number of 0.68 (p = 0.03).

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Mutagenicity of fume particles from metal arc welding on stainless steel in the Salmonella/microsome test

Cited by 70 publications

References 5 publications

Assessment of occupational exposure to welding fumes by inductively coupled plasma‐mass spectroscopy and by the alkaline Comet assay

Assessment of occupational exposure to welding fumes by inductively coupled plasma‐mass spectroscopy and by the alkaline Comet assay

Incidence of cancer among welders and other workers in a Norwegian shipyard.

A retrospective cohort study of mortality among stainless steel welders.

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