Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in salmonella/microsome assay

Nagabhushan, M.; Amonkar, A.J.; Bhide, S. V.

doi:10.1016/0304-3835(87)90094-2

Cited by 56 publications

(22 citation statements)

References 8 publications

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“…In spite of the GNs and SGs exhibiting anticancer activities towards numerous cell lines, ginger metabolites were found to be mutagenic towards certain Salmonella typhimurium strains, upon metabolic activation (Nagabhushan et al, 1987), and towards Escherichia coli Strain Hs30 (Nakamura and Yamamoto, 1983). Ginger extract was found to be weakly mutagenic towards some of the S. typhimurium strains (TA 100 and TA 1535) and 6-GN proved to be more mutagenic than 6-SG (Nagabhushan et al, 1987).…”

Section: Anticancer Activitymentioning

confidence: 85%

Gingerols and shogaols: Important nutraceutical principles from ginger

et al. 2015

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Section: Anticancer Activitymentioning

confidence: 85%

Gingerols and shogaols: Important nutraceutical principles from ginger

et al. 2015

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“…Although our study found that the ginger extract was not genotoxic, previous studies suggest that ginger contains mutagenic (gingerol and shogoal) as well as antimutagenic (zingerone) compounds Yamamoto, 1982, 1983;Nagabhushan et al, 1987;Soudamini et al, 1995]. Treatment with crude aqueous ginger (0.5-10 g/kg body weight, i.g.)…”

mentioning

confidence: 78%

Effects of ginger (Zingiber officinale Roscoe) on DNA damage and development of urothelial tumors in a mouse bladder carcinogenesis model

Bidinotto

Spinardi-Barbisan

Rocha

et al. 2006

Environ and Mol Mutagen

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Extracts of the spice ginger (Zingiber officinale Roscoe) are rich in gingerols and shogaols, which exhibit antioxidant, anti-inflammatory, antifungal, antimycobacterial, and anticarcinogenic proprieties. The present study evaluated the chemoprotective effects of a ginger extract on the DNA damage and the development of bladder cancer induced by N-butyl-N-(4-hydroxibutyl) nitrosamine (BBN)/N-methyl-N-nitrosourea (MNU) in male Swiss mice. Groups G1-G3 were given 0.05% BBN in drinking water for 18 weeks and four i.p. injections of 30 mg/kg body weight MNU at 1, 3, 10, and 18 weeks. Group G4 and G5 received only the BBN or MNU treatments, respectively, and groups G6 and G7 were not treated with BBN or MNU. Additionally, Groups G2, G3, and G6 were fed diets containing 1, 2, and 2% ginger extract, respectively, while Groups G1, G4, G5, and G7 were fed basal diet. Samples of peripheral blood were collected during the experiment for genotoxicity analysis; blood collected 4 hr after each MNU dose was used for the analysis of DNA damage with the Comet assay (assay performed on leukocytes from all groups), while reticulocytes collected 24 hr after the last MNU treatment of Groups G5-G7 were used for the micronucleus assay. At the end of the experiment, the urinary bladder was removed, fixed, and prepared for histopathological, cell proliferation, and apoptosis evaluations. Ginger by itself was not genotoxic, and it did not alter the DNA damage levels induced by the BBN/MNU treatment during the course of the exposure. The incidence and multiplicity of simple and nodular hyperplasia and transitional cell carcinoma (TCC) were increased by the BBN/MNU treatment, but dietary ginger had no significant effect on these responses. However, in Group G2 (BBN/MNU/2% ginger-treated group), there was an increased incidence of Grade 2 TCC. The results suggest that ginger extract does not inhibit the development of BBN-induced mouse bladder tumors.

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“…The inhibition of the mutagenicity of known mutagens by plant extracts, which by themselves are not mutagenic, is a well-known phenomenon. For instance the spice, turmeric (Curcuma longa L) and its yellow pigment, curcumin, were non-mutagenic but a diet that included 1% turmeric reduced benzo(a)pyrene (BaP)-and DMBA-induced stomach tumours and spontaneous mammary tumours in mice (Nagabhushan & Bhide, 1985;Nagabhushan et al, 1987a;Nagabhushan et al, 1987b) and curcumin inhibited the mutagenicity of benzo[a]pyrene and dimethyl benzo [a] anthracene in a dose-dependent manner in Salmonella typhimurium strain TA98 in the presence of S-9 mix (Nagabhushan et al, 1987a). The observations were interpreted to mean that curcumin may alter the metabolic activation and detoxification of mutagens (Nagabhushan et al, 1987a).…”

Section: Discussionmentioning

confidence: 99%

Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

Asita¹,

Heisi²,

Tjale³

2015

ENRR

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Methanolic extracts (mg mL -1 ) of Dicoma anomala (0.0625, 0.125, 0.25), Chenopodium album (0.078, 0.156, 0.313), used in traditional medicine in Lesotho, and Camellia sinensis (0.1094, 0.2085, 0.44) were assessed for cytotoxicity, genotoxicity and modulation of Cyclophosphamide (CP 1.25 mg mL -1 ) -and EMS (0.25 mg mL -1 )-induced genotoxicity using the Allium cepa assay following 24 hours treatment. Cytotoxicity was measured by the mitotic index (MI). Genotoxicity (GT) was expressed as the number of aberrant mitotic cells per 100 mitotic cells. The MI and GT of test groups (triplicates), were compared with the negative (water) control group using t-test. Modulatory effect (ME) was calculated as, ME(%) = (1-(A-B)/(A-C) × 100) -1. A positive ME indicated an increase (synergism or potentiation) while a negative ME indicated a reduction (anti-genotoxicity) of mutagen-induced genotoxicity. The concentrations of D. anomala extract were cytotoxic and genotoxic. Mixtures of CP or EMS with the lower concentrations of D. anomala extract were more genotoxic than CP (250.50% increase) or EMS (149.74 and 157.37 % increase) or extracts alone. Only 0.313 mg mL -1 of C. album extract was cytotoxic but none of the three concentrations was genotoxic. Mixtures of CP with extracts of C.album were cytotoxic. CP-induced genotoxicity was reduced (55.18, 68.36, 57.40 %) and EMS-induced genotoxicity was also reduced by low concentrations (50.72, 61.13 %) of C.album extract. However, 0.313 mg mL -1 C. album extract increased (236.75%) EMS-induced genotoxicity. C. sinensis extracts and their mixtures with CP were not cytotoxic or genotoxic. CP-induced genotoxicity was reduced (63.61, 66.62, 78.64 %) but EMS-induced genotoxicity was increased (124.97, 4.48, 110.52 %) by C. sinensis extract.

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Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in salmonella/microsome assay

Cited by 56 publications

References 8 publications

Gingerols and shogaols: Important nutraceutical principles from ginger

Gingerols and shogaols: Important nutraceutical principles from ginger

Effects of ginger (Zingiber officinale Roscoe) on DNA damage and development of urothelial tumors in a mouse bladder carcinogenesis model

Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

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