Mutagenicity of metal ions in bacteria

Arlauskas, Andrew; Baker, R.S.U.; Bonin, Antonio M.; Tandon, R.K.; Crisp, P.T.; Ellis, J.

doi:10.1016/0013-9351(85)90032-5

Cited by 78 publications

(35 citation statements)

References 20 publications

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“…Arsenite and arsenate were also negative in assays with S. typhimurium and with the tryptophan auxotrophic E. coli WP2 strain (33,47,48). Arsenite did not induce X prophage in E. coli WP2s (49).…”

Section: Short-term Testsmentioning

confidence: 95%

“…Nevertheless, in the fluctuation assay, BeS04 was mutagenic to Salmonella TA100 (but negative to other strains) and to E. coli (48). Both amber and ochre mutations were induced by BeC12 in the lad gene of E. coli, primarily involving base substitution (79).…”

Section: Short-term Testsmentioning

confidence: 99%

“…Nickel compounds are almost always negative in mutagenicity assays with S. typhimurium and E. coli. Thus, the fluctuation assay, which identified chromate, beryllium, and cadmium as mutagenic and arsenite, arsenate, and lead nitrate as nonmutagenic, was negative with nickel chloride or sulfate (48). The exption was X prophage induction in E. coli which has a much wider genetic end point (247).…”

Section: Short-term Testsmentioning

confidence: 99%

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Epidemiological and experimental aspects of metal carcinogenesis: physicochemical properties, kinetics, and the active species.

Magós

1991

Environ Health Perspect

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The carcinogenic properties ofselected metals and their compounds are reviewed to provide a useful reference for existing knowedge on relationships between physical and chemical forms, kinetics and carcnogenic potental and between epqiemiology, bioassays, and short-term testL Exteive consideation is given to arsenic, berl, cadmium, chromium, lead, and nickel. Other metas such as antimony, cobalt, copper, iron, man selnium, and zinc are discussed briefly.

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Section: Short-term Testsmentioning

confidence: 95%

Section: Short-term Testsmentioning

confidence: 99%

Section: Short-term Testsmentioning

confidence: 99%

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Epidemiological and experimental aspects of metal carcinogenesis: physicochemical properties, kinetics, and the active species.

Magós

1991

Environ Health Perspect

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“…Typhimurium TA1535 in a plate incorporation assay with a modified Vogel-Bonner medium, inducing a doubling of revertants at the highest dose tested (43.3 µg/plate, without S9) (Arlauskas et al, 1985).…”

Section: In Vitro Studies In Bacteriamentioning

confidence: 99%

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] related to the Tolerable Upper Intake Level of Vanadium

2004

EFSA Journal

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“…Over a 5-year sampling period, measured Cr 6+ concentrations in site groundwater ranged between 2.30 and 6.49 mg/ℓ. Hexavalent chromium is classified as a SABS 0228 danger group 8(II) compound leading to birth defects and reproductive impairment (Arlauskas et al 1985;DWAF, 1998;Kanojia et al, 1998). It can cross the cellular membrane via sulphate transporters and, once inside the cell, can generate reactive oxygen species (ROS), implicated as mutagens and carcinogens, from the cyclic single electron transfer between Cr 6+ , molecular oxygen and Cr 5+ (Ackerley et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effective bioreduction of hexavalent chromium–contaminated water in fixed-film bioreactors

Williams

Botes

Maleke

et al. 2014

WSA

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Hexavalent chromium (Cr 6+ ) contamination from a dolomite stone mine in Limpopo Province, South Africa, has resulted in extensive groundwater contamination. In order to circumvent any further negative environmental impact at this site, an effective and sustainable treatment strategy for the removal of up to 6.49 mg/ℓ Cr 6+ from the groundwater was developed. Laboratory-scale, continuous up-flow bioreactors were constructed to evaluate reduction of Cr 6+ , with a residence time of 24 h, an efficiency porosity of 44% and a flow rate of 1.5 mℓ/min. Stoichiometrically balancing terminal electron acceptors in the feed water with a selected electron donor, directed reactor balance for complete Cr 6+ reduction. The microbial community shifted in relative dominance during operation to establish an optimal metal-reducing community, including Enterobacter cloacae, Flavobacterium sp. and Ralstonia sp., which achieved 100% reduction. Evaluation after reactor termination with SEM-EDX and XRD confirmed the establishment of biofilm on the reactor matrix, as well as trivalent chromium (Cr 3+ ) precipitation within the reactor. Due to gravitational force, high concentrations of Cr 3+ were found in the bottom third of the reactor. Based on the results from the laboratory investigation, a 24 000 ℓ fixed-film pilot bioreactor was designed and constructed at this site. Influent flow rates, electron donor injection and automated sampling were remotely controlled by a programmable logic controller (PLC). Similar to the laboratory column study, steady state conditions could be achieved and successful Cr 6+ reduction was evident. This is the first up-scaled, effective demonstration of a biological chromium(VI) bioremediation system in South Africa.

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Mutagenicity of metal ions in bacteria

Cited by 78 publications

References 20 publications

Epidemiological and experimental aspects of metal carcinogenesis: physicochemical properties, kinetics, and the active species.

Epidemiological and experimental aspects of metal carcinogenesis: physicochemical properties, kinetics, and the active species.

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] related to the Tolerable Upper Intake Level of Vanadium

Effective bioreduction of hexavalent chromium–contaminated water in fixed-film bioreactors

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