Mutagenicity of platinum coordination complexes in Salmonella typhimurium

Beck, Doris J.; Fisch, Judith E.

doi:10.1016/0165-1218(80)90119-6

Cited by 57 publications

(11 citation statements)

References 24 publications

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“…The correlation between the mutation induction of a series of platinum compounds and their antitumor activity 16,43,44) might suggest that mutagenesis and antitumor activity are caused by the same biochemical event. However, cis-DDP induces mutations in Chinese hamster ovary cells at low frequencies, e.g., less than 200 hypoxanthine-guanine phosphoribosyl transferase (HGPRT) mutants per 10 6 cells 17).…”

Section: Structure Activity Relationsmentioning

confidence: 97%

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Johnson

Butour

Villani

et al. 1989

Progress in Clinical Biochemistry and Medicine

164

122

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Cisplatin (cis-diamminedichloroplatinum(II») is widely used in the treatment of testicular and ovarian cancers. A number of biological and biochemical results indicate that the reaction of cisplatin with DNA is responsible for the cytotoxic action of this drug. The effect of platinum compounds on the conformation and stability of DNA has been investigated and several platinum-DNA adducts have been identified in vitro and in vivo. Preliminary experiments have quantified the effect of these different lesions on DNA replication, their capacity to induce mutations and their susceptibility to DNA repair processes. Additional DNA damage may be created by platinum(IV) compounds, perhaps during their reduction to platinum(II) compounds by the cell.

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Section: Structure Activity Relationsmentioning

confidence: 97%

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Johnson

Butour

Villani

et al. 1989

Progress in Clinical Biochemistry and Medicine

164

122

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“…It is known that Pt compounds with the structure cisPtN 2 X 2 are strong mutagens (Uno and Morita 1993). The mutagenicity of transplatin is considerably lower than that of cisplatin (Beck and Fisch 1980). A great number of Pd compounds tested -among them divalent cis-complexes -failed to show any evidence for a genotoxic potential for bacterial systems.…”

Section: Genotoxicitymentioning

confidence: 99%

Platinum‐Group Metals

Hoppstock¹,

Sures²

2004

Elements and Their Compounds in the Environment

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“…Spontaneous revertants have been subtracted from dose response curves. 76 Zwelling ef uI. '~ have reported mutagenicity assays performed with mammalian V79 cells.…”

Section: Mulugenesis In Bacttv-iumentioning

confidence: 99%