Mutagenicity of some commercially available nitro compounds for Salmonella typhimurium

Chiu, Chung Wai; Lee, Langfong H.; Wang, Ching Yung; Bryan, George T.

doi:10.1016/0165-1218(78)90090-3

Cited by 168 publications

(31 citation statements)

References 9 publications

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“…A 30% increase in revertant colonies occurred reproducibly at 1 and 3% vapour concentrations in desiccator assays with strain TA100. Some authors (Chiu et al, 1978) would not regard this as a positive result, believing that at least a 100% increase in the number of revertant colonies is needed before mutagenicity is is established. Waskell (1978), who has also tested trichloroethylene in the salmonella system, concluded that it was not mutagenic.…”

Section: Discussionmentioning

confidence: 99%

Mutagenicity of Inhalation Anaesthetics: Trichloroethylene, Divinyl Ether, Nitrous Oxide and Cyclopropane *

Baden¹,

Kelley²,

Mazze³

et al. 1979

British Journal of Anaesthesia

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SUMMARYThe mutagenic potential of trichloroethylene, divinyl ether, nitrous oxide and cyclopropane was assessed in vitro by microbial assay employing two histidine-dependent strains of Salmonella typhimurium, TA1535 and TA100. Anaesthetic agents in various concentrations were incubated with bacteria in the presence or absence of an enzyme system prepared from enzyme-induced rat liver. Nitrous oxide and cyclopropane were not mutagenic, whereas divinyl ether gave a strongly positive response. Results for trichloroethylene were equivocal. These and previous studies with the salmonella system, together with mutagenicity studies using different test systems, indicate that modern inhalation anaesthetic agents are unlikely to be mutagenic.

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Section: Discussionmentioning

confidence: 99%

Mutagenicity of Inhalation Anaesthetics: Trichloroethylene, Divinyl Ether, Nitrous Oxide and Cyclopropane *

Baden¹,

Kelley²,

Mazze³

et al. 1979

British Journal of Anaesthesia

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“…The oral LD 50 in mice is 1.297 g/kg; in rats, 2.828 g/kg (2). o-Nitrophenol was negative in the Ames mutagenicity test (115), and it was metabolically reduced less readily to the corresponding amino derivative than the meta-or paraisomers (116).…”

Section: Toxic Effectsmentioning

confidence: 99%

Aromatic Nitro and Amino Compounds

Bingham¹,

McGowan²

2012

Patty's Toxicology

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Logically, aromatic nitro and amino compounds should be discussed together because their toxic responses are often similar due to a common metabolic intermediate. Synthetically, amines are generally derived from nitro compounds, but in some cases nitro compounds can be prepared through amines when other methods fail to afford specific compounds. There are good and bad attributes to these types of compounds. Some act as sensitizers and contingent on physical properties may be absorbed through the skin or mucous membranes. They may also cause methemoglobinemia, depending on such factors as the structure and the particular organism. Some members of this class are known as animal and human carcinogens; for humans, the urinary bladder is the most prominent target organ. Nevertheless, these compounds and their derivatives have enlivened our world through their use as dyestuff intermediates or as photographic chemicals, they alleviate pain as components of widely used analgesics, and they cushion or insulate us through their use in flexible and rigid foams. Other important uses include production of pesticides, including herbicides and fungicides, as ingredients in adhesives, paints and coatings, antioxidants, explosives, optical brighteners, rubber ingredients, and as intermediates in many other products.

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“…Abwesenheit von S9 Mix mit Konzentrationen bis zu 2500 ng/Platte verliefen die Untersuchungen negativ Benkendorf 1978;Chiu et al 1978;Fu et al 1985;Garner and Nutman 1977;Nohmi et al 1984;Purchase et al 1978;Suzuki et al 1983;Vance and Levin 1984). Unter Zugabe von Norharman und Anwesenheit von S9 Mix wirkte Nitrobenzol im Salmonella-typhimuriumStamm TA98 mutagen (Suzuki et al 1983;vgl.…”

Section: In Vitrounclassified

Nitrobenzol [MAK Value Documentation in German language, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 27. Lieferung, Ausgabe 1998 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

show abstract

Mutagenicity of some commercially available nitro compounds for Salmonella typhimurium

Cited by 168 publications

References 9 publications

Mutagenicity of Inhalation Anaesthetics: Trichloroethylene, Divinyl Ether, Nitrous Oxide and Cyclopropane *

Mutagenicity of Inhalation Anaesthetics: Trichloroethylene, Divinyl Ether, Nitrous Oxide and Cyclopropane *

Aromatic Nitro and Amino Compounds

Nitrobenzol [MAK Value Documentation in German language, 1998]

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