Mutagenicity Study

Abstract

Biometric methods are discussed for analyzing data from bioassays of mutagenic response. Emphasis is placed on the classic microbial system in environmental mutagenesis: the Ames/ Salmonella microsome assay. The assay produces count data to quantify the mutational response; statistical issues of interest when analyzing such data include testing for extra‐Poisson variability, trend testing for a dose response, and trend testing under a nonmonotone dose response.