Mutagenicity testing of nine herbicides and pesticides currently used in agriculture

Kale, P. G.; Petty, Bobby T.; Walker, Sophia; Ford, Jeffery B.; Dehkordi, N; Tarasia, Srikumar; Tasie, Bertram O.; Kale, Ranjini; Sohni, Youvraj R.

doi:10.1002/em.2850250208

Cited by 55 publications

(34 citation statements)

References 27 publications

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“…The result of the present study with a plant assay system agreed with another study with an insect assay system where it was found that exposure to Ambush (a permethrin-containing insecticide) during larval development increased sex-linked lethal mutations in fruit flies (Kale et al, 1995).…”

Section: Discussionsupporting

confidence: 90%

Cytotoxicity and genotoxicity of some agropesticides used in Southern Africa

Asita¹,

Hatane²

2012

J. Toxicol. Environ. Health Sci.

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Section: Discussionsupporting

confidence: 90%

Cytotoxicity and genotoxicity of some agropesticides used in Southern Africa

Asita¹,

Hatane²

2012

J. Toxicol. Environ. Health Sci.

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“…Industrial effluents, agricultural runoff, and municipal wastewaters contain unknown substances and complex mixtures that are released into the environment and can lead to contamination of surface and subsurface waters [Houk, 1992;Kale et al, 1995;White et al, 1996]. Compounds present in polluted water are capable of causing biological alterations that can affect particular populations and entire ecosystems [Rajaguru et al, 2003].…”

Section: Introductionmentioning

confidence: 99%

Fish as bioindicators to assess the effects of pollution in two southern Brazilian rivers using the Comet assay and micronucleus test

Andrade

Silva

et al. 2004

Environ and Mol Mutagen

105

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Industrial effluents, agricultural runoff, and municipal wastewaters contain unknown substances and complex mixtures that are released into the environment and can lead to contamination of surface and subsurface waters. In the present report, we have used the alkaline Comet assay and the micronucleus (MN) test to detect the genotoxicity due to multiple sources of pollution in the peripheral blood of two native estuarine fish (mullet and sea catfish) and evaluated possible interactive genotoxic effects from multiple contaminants and the seasonal variation of the genotoxicity. Mullet and sea catfish were captured in the Tramandai and Mampituba Rivers in the southern Brazilian state of Rio Grande do Sul. Reference animals were obtained from the Armazem lagoon. Fish captured in the two estuaries during the four seasons over a period of 2 years had increased levels of DNA damage and MN frequencies relative to the reference fish. In general, the alkaline Comet assay was more sensitive to the genotoxicity of the river contaminants than the MN test. The Comet assay demonstrated significant differences in fish captured at different seasons and at the two river sites, while the MN test showed significant differences only for the annual average for mullet from both sites and fish from the control site. The increases in DNA damage appear to be related to the increase in the number of people in the towns close to the study areas during the warm spring and summer seasons. Although no specific cause-effect relationships were established, comparison of the chemical contaminants and physical variations in the rivers with the genotoxicity data indicate that there may be some association between hydrocarbons, metals, pH, and water temperature and the level of damaged cells observed in mullet and sea catfish from the Tramandai and Mampituba estuaries.

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“…Thus, although a first report did not obtain positive induction in the sexlinked recessive lethal test after treating adult flies [Vogel and Chandler, 1974], other authors have reported slight mutagenicity in the same test following this procedure [Magnusson et al, 1977]. On the other hand, whilst no mutagenicity was obtained when the chemical was administered by feeding and/or by injection to adults [Zimmering et al, 1985], this compound was reported to be a potent mutagen when applied during larvae development [Kale et al, 1995]. It is in this context of conflicting data where we believe that our data from using the somatic mutation assay can be relevant, mainly taking into account that the quantification of the recombining activity of a compound is of primary importance for genotoxicity screening [Graf and Würgler, 1996].…”

Section: Resultsmentioning

confidence: 92%