Mutagens in rat urine after dermal application of 1,3-diaminobenzene

Mutagenicity of resorcinol formed by the reaction of m-phenylenediamine with sodium nitrite

“…However, little is known about mutagenicities and carcinogenicities of N-nitroso compounds, especially those produced by the reaction of primary amines with sodium nitrite, because of their unstable chemical properties. A recent publication has also indicated that m-phenylenediamine, a component of hair dye formulations, has significant mutagenic activity under a Salmonella/ mammalian microsome assay system (Clemmensen and Lam, 1984). Hence, the present study was initiated to find the mutagenicity of a derivative of a diazonium salt obtained by the reaction of m-phenylenediamine with sodium nitrite.…”