Mutagens in surface waters: a review

Ohe, Takeshi; Watanabe, Tetsushi; Wakabayashi, Keiji

doi:10.1016/j.mrrev.2004.08.003

Cited by 469 publications

(283 citation statements)

References 186 publications

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“…humic and fulvic acids, bromide and iodide) naturally occurring in most source waters (lakes, rivers, and groundwaters), generating a variety of highly toxic disinfection by-products (DBPs) which constitute an important public health concern [1]. Source waters are also contaminated by industrial and urban emissions, which may react with disinfectants producing additional carcinogenic DBPs [2]. Water source conditions, such as concentration of natural organic matter (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Due to its highly predictive value for genotoxic effects, the MN test is a widely employed assay, performed in a broad spectrum of eukaryotic organisms, from plants [33,34] to mammalian systems [35]. In the last two decades its application to circulating fish-erythrocytes has been proposed, because it was shown to be simple, reliable and sensitive [2,36].…”

Section: Introductionmentioning

confidence: 99%

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Modulation of cytochrome P450 and induction of DNA damage in Cyprinus carpio exposed in situ to surface water treated with chlorine or alternative disinfectants in different seasons

Canistro

Melega

Ranieri

et al. 2012

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Epidemiological studies have shown an association between consumption of disinfected drinking water and adverse health outcomes. The chemicals used to disinfect water react with occurring organic matter and anthropogenic contaminants in the source water, resulting in the formation of disinfection byproducts (DBPs). The observations that some DBPs are carcinogenic in animal models have raised public concern over the possible adverse health effects for humans. Here, the modulation of liver cytochrome P450-linked monooxygenases (MFO) and the genotoxic effects in erythrocytes of Cyprinus carpio fish exposed in situ to surface drinking water in the presence of disinfectants, such as sodium hypochlorite (NaClO), chlorine dioxide (ClO 2 ) and peracetic acid (PAA), were investigated in winter and summer. A complex induction/suppression pattern of CYP-associated MFOs in winter was observed for all disinfectants. For example, a 3.4-to 15-fold increase was recorded of the CYP2B1/2-linked dealkylation of penthoxyresorufin with NaClO (10 days) and PAA (20 days). In contrast, ClO 2 generated the most notable inactivation, the CYP2E1-supported hydroxylation of p-nitrophenol being decreased up to 71% after 10 days' treatment. In summer, the degree of modulation was modest, with the exception of CYP3A1/2 and CYP1A1 supported MFOs (62% loss after 20 days PAA).The micronucleus (MN) induction in fish circulating erythrocytes was also analysed as an endpoint of genotoxic potential in the same fish population. Significant increases of MN induction were detected at the latest sampling time on fish exposed to surface water treated with chlorinate-disinfectants, both in winter (NaClO) and summer (NaClO and ClO 2 ), while no effect was observed in fish exposed to PAA-treated water.These results show that water disinfection may be responsible for harmful outcomes in terms of MFO perturbation and DNA damage; if extrapolated to humans, they ultimately offer a possible rationale for the increased urinary cancer risk recorded in regular drinking water consumers.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modulation of cytochrome P450 and induction of DNA damage in Cyprinus carpio exposed in situ to surface water treated with chlorine or alternative disinfectants in different seasons

Canistro

Melega

Ranieri

et al. 2012

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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“…Genotoxicity tests have proven to be sensitive enough for detecting the effects of xenobiotic on aquatic organisms (Jha, 2004;Ohe et al, 2004;Smit et al, 2009). Aquatic organisms such as fish have been used as sentinels to monitor contamination with genotoxic chemicals (Lemos et al, 2007;Domingos et al, 2009) and Zebrafish used in the present study has been recently evaluated as potential in vivo model for genotoxicity (Chakravarthy et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

First Evaluation of Genotoxicity of Macaé (Rj) Estuarine Waters

Conceição¹,

Costa

Molisani³

et al. 2018

ACMAR

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“…Recently, a variety of known or unknown genotoxic compounds have become components of surface waters [31]. Several DNAdamaging agents, such as fluoroquinolone (FQ) antibiotics and nitroarenes, were identified as major mutagens in waters by combination of the SOS/umu test as a genotoxicity bioassay and HPLC as a fractionation method.…”

Section: Discussionmentioning

confidence: 99%

Assessing of genotoxicity of 16 centralized source-waters in China by means of the SOS/umu assay and the micronucleus test: Initial identification of the potential genotoxicants by use of a GC/MS method and the QSAR Toolbox 3.0

Yan

Jiang²,

Na³

et al. 2014

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Only few studies were conducted to assess genotoxicity of centralized source waters in China and almost none of them dealt with the causal relationship between the genotoxic effect and genotoxicants. In this work, 16 centralized source waters in China were sampled from five river systems and genotoxicity of their organic extracts was assessed by use of the SOS/umu test for DNA-damaging effect and the miniaturized flow cytometry-based micronucleus (MN) test for chromosome-damaging effect. In addition, initial identification of potential genotoxicants for the six samples from the Yangtze River was done with a GC/MS method and the QSAR toolbox 3.0. The results demonstrate that eight samples showed both indirect and direct DNA-damaging effects, another four samples showed only indirect DNA-damaging effects, while chromosome-damaging effects were found for 14 out of the 16 samples, in which aneugenic and clastogenic modes of action were found for 4 and 10 samples, respectively. Both direct/indirect DNAdamaging effects and chromosome-damaging effects were induced by the six Yangtze River samples, and the existing different types of genotoxicant confirmed the results. Furthermore, o-phenylphenol was initially identified as the major cause for the DNA-damaging effects while PAHs, pesticides, phenol and anthraquinone were identified as ubiquitous chromosome-damaging agents among these samples. In conclusion, a combination of the SOS/umu test and the miniaturized flow cytometry-based MN test to detect both DNA-damaging and chromosome-damaging effects could be used as a comprehensive genotoxicity assessment tool for the evaluation and classification of genotoxicity of complex mixtures, and potential genotoxicants can be initially identified with additional information from chemical analysis and the QSAR toolbox.

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Mutagens in surface waters: a review

Cited by 469 publications

References 186 publications

Modulation of cytochrome P450 and induction of DNA damage in Cyprinus carpio exposed in situ to surface water treated with chlorine or alternative disinfectants in different seasons

Modulation of cytochrome P450 and induction of DNA damage in Cyprinus carpio exposed in situ to surface water treated with chlorine or alternative disinfectants in different seasons

First Evaluation of Genotoxicity of Macaé (Rj) Estuarine Waters

Assessing of genotoxicity of 16 centralized source-waters in China by means of the SOS/umu assay and the micronucleus test: Initial identification of the potential genotoxicants by use of a GC/MS method and the QSAR Toolbox 3.0

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