2003
DOI: 10.1038/sj.onc.1206724
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Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

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Cited by 116 publications
(99 citation statements)
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“…One area in which such understanding has been gained is the antiapoptotic role of mutp53. As mentioned above, mutp53 was found to repress the CD95 promoter (Zalcenstein et al, 2003). As expected, this conferred increased resistance to killing by the CD95 ligand, when such ligand was experimentally added to the culture.…”
Section: Mechanisms Of P53 Gofsupporting
confidence: 75%
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“…One area in which such understanding has been gained is the antiapoptotic role of mutp53. As mentioned above, mutp53 was found to repress the CD95 promoter (Zalcenstein et al, 2003). As expected, this conferred increased resistance to killing by the CD95 ligand, when such ligand was experimentally added to the culture.…”
Section: Mechanisms Of P53 Gofsupporting
confidence: 75%
“…For example, transcriptional regulation of the MDR-1 promoter by wtp53 and by mutp53 is mediated by different promoter regions (Sampath et al, 2001) and similar observations were demonstrated for CD95 (Zalcenstein et al, 2003), suggesting that the assembly of functionally distinct complexes may be determined by different mechanisms. Either way, it seems that the functional consequence of mutp53 presence in the complex is tumor promotion while the presence of wtp53 results in tumor suppression.…”
Section: Mutp53: Role Of Residual Wtp53 Activity?supporting
confidence: 53%
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