Mutant Plant Tipobio Variety of Rodent Tuber (Typhonium Flagelliforme): Fatty Acids Compounds and in Vitro Anticancer Activity

Sianipar, Nesti Fronika; Assidqi, Khoirunnisa; Hadisaputri, Yuni Elsa; Salam, Supriatno; Purnamaningsih, Ragapadmi; So, Idris Gautama

doi:10.1051/e3sconf/202338801032

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Zingiber officinale and P. niruri are also therapeutic herbs that work as immune system regulators and prevent kidney stones and hepatitis. Typhonium flagelliforme has also been used to treat cancer, infection, cough, and allergy problems (Sianipar et al 2023;Farida et al 2014;Alfarabi et al 2015). All these possibilities are possible due to the bioactive chemicals present.…”

Section: Introductionmentioning

confidence: 99%

Understanding of genes encoding bioactive compounds from potential medicinal plants in Indonesia as cancer cell inhibitors

MUFLIKHATI,

SIANIPAR,

SYAMSUNARNO

et al. 2023

Biodiversitas

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Abstract. Muflikhati Z, Sianipar NF, Syamsunarno MRAA, Anas. 2023. Understanding of genes encoding bioactive compounds from potential medicinal plants in indonesia as cancer cell inhibitors. Biodiversitas 24: 4645-4660. Indonesia has abundant plant diversity and enormous potential to be developed as a source of medicinal plants due to the content of bioactive chemicals in them. Potential medicinal plants from Indonesia, such as Andrographis paniculata (Sambiloto), Curcuma longa (Kunyit), Moringa oleifera (Moringa), Phyllanthus niruri (Meniran), Orthosiphon stamineus (Kumis kucing), Typhonium flagelliforme (Keladi tikus), and Zingiber officinale (Jahe), contain bioactive compounds with mechanisms that act as anticancer. Bioactive compounds with anticancer mechanisms in plants can be controlled by specific genes. Therefore, it is important to elaborate on bioactive compounds and the genes involved. This article aims to discuss the genes encoding bioactive compounds in Indonesian medicinal plants and the mechanisms that can inhibit cancer cell growth. Several genes encode anticancer compounds, such as lectin-coding genes, the stigmasterol-coding CYP710A gene, the tocopherol-coding ?-TMT gene, the fatty acid-coding FAD gene, the doxorubicin-coding DXR gene, and the chalcone synthase-coding CHS gene. These genes have mechanisms to increase the expression of several apoptosis-promoting proteins, including BCL-2 family members, in several cancer cell models. This article also describes the potential utilization and creation of molecular markers linked to genes encoding anticancer chemicals and can be used as a reference for research on medicinal plants that is still limited. Knowledge of genes encoding anticancer compounds in plants can support future research in the development of cancer drugs.

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Section: Introductionmentioning

confidence: 99%

Understanding of genes encoding bioactive compounds from potential medicinal plants in Indonesia as cancer cell inhibitors

MUFLIKHATI,

SIANIPAR,

SYAMSUNARNO

et al. 2023

Biodiversitas

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Identification of molecules from tomato plant residues using sustainable green chemicals

Drescher,

Schwingshackl,

Kienberger

2024

Biomass Conv. Bioref.

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High quantities of biomass produced in greenhouses create environmental problems as this side stream, and its downgraded products are not further used in the production cycle. The aim of our research was the identification and semi-quantification of molecules extracted from vegetative tomato plant residues with sustainable green alternative solvents using vacuum-assisted soxhlet and solid–liquid extraction to evaluate the possibilities for high-value applications for the first time. To identify compounds, gas chromatography–mass spectrometry (GC–MS) analysis and the Folin–Ciocalteau method were used. In sum, 285 different compounds have been assigned to 383 detected peaks using GC–MS analysis. The solvents 2-methyltetrahydrofuran (2-MTHF) and ethyl acetate, compared with ethanol and hexane, provided better results with a maximum number of 99 ± 8.83 compounds, a maximum total concentration of 5894.82 ± 586.48 and 3363.02 ± 71.14 mg naphthalene equivalent (NEQ) kgdw−1, and a total phenolic content of 2143.25 ± 155.17 and 1605.92 ± 66.46 mg gallic acid equivalent (GAE) kgdw−1, respectively. With 781.2 ± 112.66 and 718.25 ± 54.89 mg NEQ kgdw−1, the compound neophytadiene was the most common terpene in ethyl acetate and 2-MTHF extracts, respectively. It can be concluded that vegetative tomato plant residues contain a large variety of bioactive molecules. Green solvents, such as 2-MTHF and ethyl acetate, enhance the extraction of these molecules from the solid matrix. Graphical abstract

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Anticancer Potential of Tocopherols-Containing Plants and Semi-Synthetic Tocopherols

Sianipar,

Muflikhati,

Mangindaan

et al. 2024

Plants

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Tocopherols, potent bioactive compounds with anticancer properties, remain understudied in herbal medicinal plants, presenting a significant knowledge gap in the field of natural anticancer agents. This review evaluates tocopherol-containing plants for their anticancer potential, analyzing Scopus publications from 2016 to 2024. Fifteen herbal medicinal plants were identified as promising candidates, including Bulbine anguistifolia Poelln, Punica granatum L., Moringa oleifera, Kigelia pinnata, and Typhonium flagelliforme Lodd. The review explores tocopherols’ anticancer mechanisms, including apoptosis induction and cell cycle arrest. Factors influencing tocopherols’ anticancer effects are examined, such as their forms (α, β, γ, δ), concentrations, plant parts utilized, and their stability in various plants. Additionally, emerging research on semi-synthetic tocopherol derivatives is analyzed, highlighting their potential as adjuvants in chemotherapy and their role in enhancing drug delivery and reducing side effects. This comprehensive analysis aims to advance the development of plant-based anticancer pharmaceuticals and improve cancer treatment strategies. By elucidating the mechanisms and potential of tocopherol-containing plants, this review provides a foundation for future research in plant-based anticancer therapies. It emphasizes the need for further investigation into these plants’ anticancer properties, potentially leading to novel, more effective, and less toxic cancer therapies. The findings presented here contribute to a nuanced understanding of how tocopherol-containing plants can be leveraged in the development of future anticancer drugs.

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Mutant Plant Tipobio Variety of Rodent Tuber (Typhonium Flagelliforme): Fatty Acids Compounds and in Vitro Anticancer Activity

Cited by 3 publications

References 21 publications

Understanding of genes encoding bioactive compounds from potential medicinal plants in Indonesia as cancer cell inhibitors

Understanding of genes encoding bioactive compounds from potential medicinal plants in Indonesia as cancer cell inhibitors

Identification of molecules from tomato plant residues using sustainable green chemicals

Anticancer Potential of Tocopherols-Containing Plants and Semi-Synthetic Tocopherols

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