2002
DOI: 10.1038/modpathol.3880506
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Mutation Analysis of Human Cytokeratin 8 Gene in Malignant Rhabdoid Tumor: A Possible Association with Intracytoplasmic Inclusion Body Formation

Abstract: The rhabdoid cell, which is typically observed in malignant rhabdoid tumor (MRT) and other malignant neoplasms, has an eosinophilic cytoplasm containing a spheroid perinuclear inclusion body. This distinct cell is known to act as a highly aggressive indicator in many types of malignant tumors and is characterized by aggregates of intermediate filaments, comprising both vimentin and cytokeratin (CK) 8, which is mainly expressed in simple-type epithelium such as liver and intestine. To clarify the cause of the i… Show more

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Cited by 28 publications
(16 citation statements)
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“…We employed a previously reported method for the preparation of sections from cultured cells to cell blocks (Xu et al 1994;Shiratsuchi et al 2002). The immunohistochemical , an antibody to the underphosphorylated RB gene product (clone G99-549; 1:25; 15 min microwave; BD Pharmingen™).…”
Section: Immunohistochemistrymentioning
confidence: 99%
“…We employed a previously reported method for the preparation of sections from cultured cells to cell blocks (Xu et al 1994;Shiratsuchi et al 2002). The immunohistochemical , an antibody to the underphosphorylated RB gene product (clone G99-549; 1:25; 15 min microwave; BD Pharmingen™).…”
Section: Immunohistochemistrymentioning
confidence: 99%
“…35 Another study suggests that cytokeratin 8 gene (KRT 8) mutations result in the formation of intracytoplasmic intermediate filament inclusions. 36 Therefore, it is possible that the rhabdoid morphology may arise through similar molecular mechanisms regardless of the histogenesis. Nevertheless, distinguishing composite rhabdoid tumors from malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors remains important given differences in therapeutic approach.…”
mentioning
confidence: 99%
“…Most commonly, these are keratin filaments and can be highlighted by low and high molecular weight keratin immunohistochemical stains [24,25]. In rare instances, such as this case, the intermediate filaments are highlighted by neurofilament markers [9,26].…”
Section: Case Reportmentioning
confidence: 94%