Mutation analysis of the <i>BCL10</i> gene in childhood solid malignancies

Miao, Jiangyong; Kusafuka, Takeshi; Udatsu, Yuko; Okada, Akira

doi:10.1002/mpo.10156

Cited by 2 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46,47 In ALL, acquired 1q duplication and hyperdiploidy have been associated with increased remission rates and longer survival times in de novo disease; however, if present after relapse, the prognosis is poor. 48 Duplication of 1q11-21 seems to represent increased malignancy. 49,50 Within T-cell ALL, 1p32 deletion is a common gene mutation.…”

Section: Chromosome 1 Deletion and Duplication In Malignant Diseasesmentioning

confidence: 95%

Acute Lymphoblastic Leukemia in a Patient With Constitutional Chromosome 1pter-p36.31 Duplication and 1q43-qter Deletion

Khan

Toews

Wang

et al. 2012

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Chromosome 1 is the largest of all human chromosomes, containing 3141 genes. It is linked to 890 known genetic diseases including congenital hypothyroidism, hemochromatosis, and prostate cancer. Recognized deletion and duplication syndromes have been described. Deletions in the short arm (p) of the chromosome have been identified in tumors of the brain and kidneys. Duplications in the long (q) arm of the chromosome are reported in myelodysplastic syndromes. Solitary 1p36 deletion or 1q42 duplication are rarely reported entities and their associations with malignancy have not been characterized. We report a case of a child with constitutional 1pter-p36.31 duplication and 1q43-qter deletion who developed acute lymphoblastic leukemia (ALL). The patient's oncologic presentation and subsequent clinical course raise the question of the association of the underlying genetic abnormality and its malignant potential, specifically in relation to ALL. Acquired chromosome 1 deletions and duplications have been well described in other malignant diseases. Constitutional chromosome 1p duplication and 1q deletions have not been described with ALL.

show abstract

Section: Chromosome 1 Deletion and Duplication In Malignant Diseasesmentioning

confidence: 95%

Acute Lymphoblastic Leukemia in a Patient With Constitutional Chromosome 1pter-p36.31 Duplication and 1q43-qter Deletion

Khan

Toews

Wang

et al. 2012

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

show abstract

Expression of BCL10 is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan

et al. 2009

View full text Add to dashboard Cite

Mutation analysis of the BCL10 gene in childhood solid malignancies

Abstract: This study represents the first genetic analysis of the BCL10 gene in pediatric solid malignant tumors. Our results suggest that BCL10 mutation as a mechanism involved in tumorigenesis is unlikely to be associated with most childhood malignancies.

Cited by 2 publications

References 23 publications

Acute Lymphoblastic Leukemia in a Patient With Constitutional Chromosome 1pter-p36.31 Duplication and 1q43-qter Deletion

Acute Lymphoblastic Leukemia in a Patient With Constitutional Chromosome 1pter-p36.31 Duplication and 1q43-qter Deletion

Expression of BCL10 is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan

Contact Info

Product

Resources

About