1978
DOI: 10.1016/0042-6822(78)90067-3
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Mutation in bacteriophage T3 affecting host cell lysis

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Cited by 25 publications
(8 citation statements)
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“…In contrast, gp17.5 is not essential for T7 lysis. Consistent with earlier evidence from T3 ( Miyazaki et al 1978 ), cells infected by T7 Δ 17.5 lyzed after 16.6 min, only 2.8 min later than lysis of T7 + (13.8 min, P < 0.0002; fig. 3 ).…”
Section: Resultssupporting
confidence: 91%
See 1 more Smart Citation
“…In contrast, gp17.5 is not essential for T7 lysis. Consistent with earlier evidence from T3 ( Miyazaki et al 1978 ), cells infected by T7 Δ 17.5 lyzed after 16.6 min, only 2.8 min later than lysis of T7 + (13.8 min, P < 0.0002; fig. 3 ).…”
Section: Resultssupporting
confidence: 91%
“…The gene is usually nonessential if it includes a decimal.) Surprisingly, nonsense mutants of gene 17.5 plate at normal efficiency in a nonsuppressing host, although lysis of liquid cultures is somewhat delayed in gene 17.5 nonsense mutants of the related phage T3 ( Miyazaki et al 1978 ). Another indication that T7 may contain additional holins is the partial failure of an optimality model to predict lysis time evolution ( Heineman and Bull 2007 ).…”
Section: Introductionmentioning
confidence: 99%
“…This should not have inhibited interest in T7 lysis, since the only detectable lysozyme activity was found, early on, to be irrelevant to the lysis process (271). Despite this surprising and unprecedented finding, only one effort has been reported in which lysis mutants were explicitly sought (214). Thus, even though T7 phage has survived and even thrived in the eukaryotic era as a consequence of its marvelously powerful systems for macromolecular synthesis, the T7 lysis phenomenon has languished unattended for years.…”
Section: Perspective and Modelmentioning
confidence: 99%
“…However, the cells failed to continue dividing and thus were infected and killed by T7. The lysis protein of both T3 and T7 is thought to be a class III protein located between genes 17 and 19, perhaps the gene 17.5 product (13,18). This region of the hybrid phage B02 is thought to be of T7 origin and is genetically unlinked to the T3-derived Ml and M2 regions, which are required for growth on male strains.…”
Section: Resultsmentioning
confidence: 99%