2013
DOI: 10.1016/j.legalmed.2013.03.003
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Mutation rate at 17 Y-STR loci in “Father/Son” pairs from moroccan population

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Cited by 14 publications
(4 citation statements)
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“…In addition, two tetranucleotide microsatellites loci DYS385 and 389II appeared to consist of higher average mutation rates among all 17 Y-STRs analyzed compared to all other trinucleotide and dinucleotide microsatellite loci [ 9 ]. Similar locus specific mutation characteristics were found in Moroccan's population in a sample of 252 father-son pairs using 17 Y-STRs loci by Laouina [ 11 ] in which average locus specific mutation rate was higher at tetra nucleotide microsatellites loci. This higher mutation rate on tetranucleotide microsatellites was also observed by Kayser et al [ 1 ] using 15 Y-STRs loci for a total of 4999 male germline transmission from father-son pairs of previously confirmed paternity.…”
Section: Resultssupporting
confidence: 77%
See 1 more Smart Citation
“…In addition, two tetranucleotide microsatellites loci DYS385 and 389II appeared to consist of higher average mutation rates among all 17 Y-STRs analyzed compared to all other trinucleotide and dinucleotide microsatellite loci [ 9 ]. Similar locus specific mutation characteristics were found in Moroccan's population in a sample of 252 father-son pairs using 17 Y-STRs loci by Laouina [ 11 ] in which average locus specific mutation rate was higher at tetra nucleotide microsatellites loci. This higher mutation rate on tetranucleotide microsatellites was also observed by Kayser et al [ 1 ] using 15 Y-STRs loci for a total of 4999 male germline transmission from father-son pairs of previously confirmed paternity.…”
Section: Resultssupporting
confidence: 77%
“…The observed locus specific mutation rate ranged between 0 for DYS19, DYS389I, DYS390, DYS391, DYS392, DYS393, DYS437, DYS348, DYS439, DYS448, DYS456, DYS458, DYS635, and Y-GATA-H4 loci and 1.765 × 10 −3 (1.43x10 −4 – 4.243x10 −3 ) for DYS385a locus at 95% CI [ 9 ]. Among 100 father-son pairs analyzed at the same 17 Y-STRs loci, there was no observation of multiple Y-chromosome microsatellite mutation within the same germline transmission or nonuniform alleles such as microvariants, duplication, and triplication that have been previously reported by Laouina [ 11 ] in Moroccan population.…”
Section: Resultsmentioning
confidence: 68%
“…The generated profiles were demonstrated to be applicable to forensic, paternity, population and genetic mapping studies. homoplasy-free markers, whereas STRs have the potential to change in number of repeats [30]. With additional Alu dimorphisms being identified with techniques such as anchored PCR [23], subtractive hybridization [31], and DNA sequencing of genomes [32], then Alubased systems have great potential to advance as a formidable tool in forensic analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Some of the published reports 51 , 56 , 58 , 61 , 63 do not indicate the alleles observed in the mutation, providing only information on the type of mutation observed (single- or multistep, gain or loss of repeats). These works were thus not included in the analyses involving the number of repeats.…”
Section: Methodsmentioning
confidence: 99%