Mutation research

Auerbach, C.

doi:10.1007/978-1-4899-3103-0

Cited by 103 publications

(27 citation statements)

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“…The classic mutation analysis in Drosophila first demonstrated the transmission of genomic instability to subsequent generations of males treated with X-rays and mustard gas (Auerbach, 1976). Unfortunately however, the marker of mutation used in these classic studies was the lethality which tells little about the nature of mutation.…”

Section: Radiation Induction Of Transgenerational Genomic Instabilitymentioning

confidence: 99%

Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies

Niwa

2003

Oncogene

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Many studies confirmed that radiation induces genomic instability in whole-body systems. However, the results of the studies are not always consistent with each other. Attempts are made in the present review to resolve the discrepancies. Many of the studies in human and experimental animals utilize the length change mutation of minisatellite sequences as a marker of genomic instability. Minisatellite sequences frequently change their length, and the data obtained by conventional Southern blotting give rather qualitative information, which is sometimes difficult to scrutinize quantitatively. This is the problem inevitably associated with the study of minisatellite mutations and the source of some conflicts among studies in humans and mice. Radiation induction of genomic instability has also been assessed in whole-body experimental systems, using other markers such as the mouse pink-eyed unstable allele and the specific pigmentation loci of medaka fish (Oryzias latipes). Even though there are some contradictions, all these studies have demonstrated that genomic instability is induced in the germ cells of irradiated parents, especially of males, and in offspring born to them. Among these, transmission of genomic instability to the second generation of irradiated parents is limited to the mouse minisatellite system, and awaits further clarification in other experimental systems.

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Section: Radiation Induction Of Transgenerational Genomic Instabilitymentioning

confidence: 99%

Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies

Niwa

2003

Oncogene

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“…Transgenerational destabilization of genome was first reported for the induction of the lethal mutation in germ cells of the subsequent generations of mustard gas-treated Drosophila melanogaster (40). Transgenerational carcinogenesis and teratogenesis might also be the manifestation of the genomic instability in somatic cells of F 1 mice born to irradiated parents (41,42).…”

Section: ϫ2mentioning

confidence: 99%

Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F1 mice born to irradiated spermatozoa

Niwa¹

2001

Proceedings of the National Academy of Sciences

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Length change mutation at the Ms6hm hypervariable mouse minisatellite locus was analyzed in C57BL͞6N ؋ C3H͞HeN F 1 mice and the F1 of the reciprocal cross born to irradiated male parents. Spontaneous mutant frequencies were 8.4% and 9.8% for the paternally derived and maternally derived C3H͞HeN alleles, respectively. The mutant frequencies for the paternally derived allele increased to 22% and 19% when the male parents were irradiated with 6 Gy at the postmeiotic spermatozoa stage and the spermatogonia stage, respectively. These increases in the mutant frequency were at least 10 to 100 times higher than those expected from the frequency of hits to the 3-to 4-kb allele, suggesting that the length change mutation at this minisatellite locus was not a targeted event due directly to DNA damage in the region. Further analysis demonstrated that the mutant frequency increased also at the maternally derived C3H͞HeN allele to 20% when the male parents were irradiated at the spermatozoa stage. This increase in the maternal allele mutation was not observed in F 1 born to irradiated spermatogonia. The present study suggests that introduction of DNA damage by irradiated sperm triggers genomic instability in zygotes and in embryos of subsequent developmental stages, and this genomic instability induces untargeted mutation in cis at the paternally derived minisatellite allele and in trans at the maternally derived unirradiated allele. Untargeted mutation revealed in the present study defines a previously unnoticed genetic hazard to the maternally derived genome by the paternally introduced DNA damage.

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“…Mutation events are "spontaneous" only because we do not know all of their causes. Environmental influences such as temperature, age, transcription crrors, and mutagenic and infectious agents are well-known, but probably play a comparatively minor role in natural populations (Auerbach, 1976;Woodruff et al, 1982). Much more potent are genetic modifiers which appear to be at least indirectly involved in the evolution of mutation rates.…”

Section: Nomadic Dna and Mutation Ratesmentioning

confidence: 99%

A model for spontaneous mutation in Drosophila caused by transposing elements

Thompson

Woodruff

1981

Heredity

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SUMMARYTransposing genetic elements make up a significant proportion of the DNA of at least some eukaryotes. One of the potential side effects of transposition is a high rate of apparently spontaneous mutation. In this paper we consider some of the evolutionary strategies that might be involved in the suppression of transposition, and we outline a model for the control of spontaneous mutation in terms of the regulation of transposition. Specific predictions are based upon the well-characterized genetics of the mutator system associated with hybrid dysgenesis in Drosophila melanogaster, which has many parallels with the expected behaviour of transposing elements.

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Mutation research

Cited by 103 publications

References 0 publications

Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies

Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies

Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F1 mice born to irradiated spermatozoa

A model for spontaneous mutation in Drosophila caused by transposing elements

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