Mutation Scanning of the P53 Tumor Supressor Gene in Renal and Liver Transplant Patients in Hungary

Determining the effectiveness of High Resolution Melting analysis for SNP genotyping and mutation scanning at the TP53 locus

“…The HRM technique has been used to mutation scan the coding sequences of several clinically important genes [ 21 - 26 ]. For instance, 3 studies have reported mutation screening of TP53 exonic regions [ 21 , 22 , 27 ]. In this manuscript, we describe lessons learned from a larger scale application of HRM to mutation screening and genotyping at the entire TP53 locus.…”