Mutational analysis and clinical investigations of medically diagnosed GSD 1a patients from Pakistan
Bushra Gul,
Sabika Firasat,
Tayyaba Shan
et al.
Abstract:Glycogen storage disease type I (GSD I) is a rare autosomal recessive inborn error of carbohydrate metabolism caused by the defects of glucose-6-phosphatase complex (G6PC). Disease causing variants in the G6PC gene, located on chromosome 17q21 result in glycogen storage disease type Ia (GSD Ia). Age of onset of GSD Ia ranges from 0.5 to 25 years with presenting features including hemorrhage, hepatic, physical and blood related abnormalities. The overall goal of proposed study was clinical and genetic character… Show more
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