2021
DOI: 10.1016/j.genrep.2021.101024
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Mutational analysis of SARS-CoV-2 ORF8 during six months of COVID-19 pandemic

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Cited by 35 publications
(29 citation statements)
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“…We also identified many interactions between Nsps and accessory proteins, indicating that the possible roles of accessory proteins in the replication/transcription of viral RNAs. 5 self-interactions, Nsp3, Nsp5, Nsp15, and N reported here were also found in SARS-CoV, except for ORF8, which is one of the most distinct ORFs between SARS-CoV and SARS-CoV-2 [ 23 , 24 ]. We failed in screening out the several known interactions, such as Nsp7/Nsp12 and Nsp7/Nsp8.…”
Section: Resultssupporting
confidence: 54%
“…We also identified many interactions between Nsps and accessory proteins, indicating that the possible roles of accessory proteins in the replication/transcription of viral RNAs. 5 self-interactions, Nsp3, Nsp5, Nsp15, and N reported here were also found in SARS-CoV, except for ORF8, which is one of the most distinct ORFs between SARS-CoV and SARS-CoV-2 [ 23 , 24 ]. We failed in screening out the several known interactions, such as Nsp7/Nsp12 and Nsp7/Nsp8.…”
Section: Resultssupporting
confidence: 54%
“…ORF8 (of SARS-CoV-2 and SARS-CoV) play crucial roles in virus pathophysiological events, it dysregulates the TGF-β pathway, which is involved in tissue fibrosis [18]. The functional implications of SARS-CoV-2 ORF8 had already gained huge attention and ORF8 is considered an important component of the immune evasion machinery [11,18,19,20]. The SARS-CoV-2 ORF8 protein has less than twenty percent amino acid sequence homology with the SARS-CoV ORF8, and is a rapidly evolving protein [14,21].…”
Section: Introductionmentioning
confidence: 99%
“…Currently antibodies against the nucleocapsid phosphoprotein are used for this purpose, however, our analysis of longitudinal samples shows that nucleocapsid serology displays poor sensitivity over time (Supplementary Figure 1E). SARS-CoV-2 non-structural proteins such as open reading frame ORF-8 and ORF-3b 66,67 have been identified as alternate antibody targets, which in combination may improve sensitivity for detecting previous SARS-CoV-2 infection. These and other non-spike viral epitopes 68 constitute a promising strategy to distinguish past SARS-CoV-2 infection from vaccination.…”
Section: Discussionmentioning
confidence: 99%