Mutational approach for enhancement of artemisinin in Artemisia annua

Al‐Qurainy, Fahad; Khan, Salim

doi:10.1016/j.jbiotec.2010.09.708

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…In the present study, compounds antimutagenicity was evaluated against direct acting mutagen NaN 3 . Its mutagenicity is connected with the production of organic metabolite ( l ‐azidoadenine) that enters the nucleus and interacts with DNA . Tested compounds could exert their antimutagenic effects through various mechanisms, including antioxidant potency, inhibition of mutagen activation, or direct chemical interaction with a mutagen.…”

Section: Discussionmentioning

confidence: 99%

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4‐substituted 1‐(2‐methoxyphenyl)piperazine derivatives

Słoczyńska

Pańczyk

Waszkielewicz

et al. 2016

J Biochem & Molecular Tox

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In vitro mutagenic, antimutagenic, and antioxidant potency evaluation and biotransformation of six novel 4-substituted 1-(2-methoxyphenyl)piperazine derivatives demonstrating antidepressant-like activity were investigated. Mutagenic and antimutagenic properties were assessed using the Ames test; free radical scavenging activity was evaluated with 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay and biotransformation was performed with liver microsomes. It was found that all tested compounds are not mutagenic in bacterial strains TA100 and TA1535 and exhibit antimutagenic effects in the Ames test. Noteworthy, compounds possessing propyl linker between phenoxyl and N-(2-methoxyphenyl)piperazine displayed more pronounced antimutagenic properties than derivatives with ethoxyethyl linker. Additionally, compounds 2 and 6 in vitro biotransformation showed that primarily their hydroxylated or O-dealkylated metabolites are formed. Some of the compounds exhibited intrinsic clearance values lower than those reported previously for antidepressant imipramine. To sum up, the results of the present study might represent a valuable step in designing and planning future studies with piperazine derivatives.

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Section: Discussionmentioning

confidence: 99%

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4‐substituted 1‐(2‐methoxyphenyl)piperazine derivatives

Słoczyńska

Pańczyk

Waszkielewicz

et al. 2016

J Biochem & Molecular Tox

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show abstract

“…Reports indicate that the amount of artemisinin in tetraploid plants has increased up to 56% compared to diploid plants. Alternatively, induced mutation using chemicals such as sodium azide (NaN 3 ) and ethyl methane sulfonate (EMS) was effective in increasing the artemisinin biosynthesis in native plant ( Al-Qurainy and Khan, 2010 ; Leow et al, 2020 ).…”

Section: Treatments Impacting Artemisinin Content In Artemi...mentioning

confidence: 99%

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

et al. 2022

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Graphical AbstractThree anti-SARS-CoV-2 potentials of artemisinin and artesunate. Artemisinin (ART) and artesunate (AS) may (1) block interaction of viral spike protein with the human ACE2 receptors, preventing viral endocytosis and activation of the NF-κB signaling pathway, (2) ART and AS may block activation of NF-κB signaling pathway by IKK, or (3) may interfere directly with p50/p65 transcriptional activity in human cells.

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Mutational approach for enhancement of artemisinin in Artemisia annua

Cited by 2 publications

References 30 publications

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4‐substituted 1‐(2‐methoxyphenyl)piperazine derivatives

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4‐substituted 1‐(2‐methoxyphenyl)piperazine derivatives

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

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