2024
DOI: 10.1002/ijc.35148
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Mutational signatures and their association with cancer survival and gene expression in multiple cancer types

Peeter Karihtala,
Outi Kilpivaara,
Katja Porvari

Abstract: Different endogenous and exogenous mutational processes cause specific patterns of somatic mutations and mutational signatures. Although their biological research has been intensive, there are only rare studies assessing the possible prognostic role of mutational signatures. We used data from The Cancer Genome Atlas to study the associations between the activity of the mutational signatures and four survival endpoints in 18 types of malignancies. We further explored the prognostic differences according to, for… Show more

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