Mutations, Chromosomal Aberrations, and Tumors in Insects Treated with Oncogenic Virus

Burdette, Walter J.; Yoon, Joonseok

doi:10.1126/science.155.3760.340

Cited by 31 publications

(6 citation statements)

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“…These protocols exploit the capacity of insertion of mobile elements, particularly the P elements of Drosophila, used as tools to introduce new genetic information into the genomes. Fahmy & Fahmy, 1966Parkash, 1967Chopra, 1970Gershenson, Alexandrov & Maliuta, 1975Shandala & Gershenson, 1988Alexandrov & Golubovsky, 1983Burdette & Yoon, 1967Gazaryan et al, 1982Gazaryan et al, 1985 Unpublished data Tatosyan et al, Gazaryan et al, 1984Gazaryan et al, 1987 Unpublished data Baumiller, 1967 Unpublished data Golubovsky & Plus, 1982Rubin & Spradling, 1982Gazaryan et al, 1985Gray et al, 1992Bucala et al, 1993Sprague & McKinney, 1966Mottinger, Dellaporta & Keller, 1984Mottinger, Johns & Freeling, 1984Dellaporta et al, 1984Johns, Mottinger & Freefing, 1985Peterson, 1985 Unaffected genome structure ltaya, 1993…”

Section: Experiments With Environmental Factorsmentioning

confidence: 96%

“…These results concern at first visible mutations or lethality, in relation with classic genetic studies. In Drosophila, numerous mutations and sex-linked lethality have been observed following ingestion or injection of foreign DNA originating from calf thymus (Chopra, 1970), sperm fish (Parkash, 1967), or from viruses non infectious for this insect like RSV (Rous Sarcoma Virus: Burdette & Yoon, 1967) and influenza virus (Alexandrov & Golubovsky, 1983). A hypothesis concerning the effect of ingestion is that DNA could pass throughout the intestinal tube, reach the germ cells and interact with the genomic material of the insect.…”

Section: Effects Of Exogenous Genomic Materials Introductionmentioning

confidence: 99%

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Genome and stresses: Reactions against aggressions, behavior of transposable elements

Arnault

Dufournel

1994

Genetica

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The action of stresses on the genome can be considered as responses of cells or organisms to external aggressions. Stress factors are of environmental origin (climatic or trophic) or of genomic nature (introduction of foreign genetic material, for example). In both cases, important perturbations can occur and modify hereditary potentialities, creating new combinations compatible with survival; such a situation may increase the variability of the genome, and allow evolutive processes to take place. The behavior of transposable elements under stress conditions is thus of particular interest, since these sequences are sources of mutations and therefore of genetic variability; they may play an important role in population adaptation. The survey of the available experimental results suggest that, although some examples of mutations and transposable elements movements induced by external factors are clearly described, environmental injuries or introduction of foreign material into a genome are not systematically followed by drastic genomic changes.

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Section: Experiments With Environmental Factorsmentioning

confidence: 96%

Section: Effects Of Exogenous Genomic Materials Introductionmentioning

confidence: 99%

Genome and stresses: Reactions against aggressions, behavior of transposable elements

Arnault

Dufournel

1994

Genetica

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“…However, both sigma and Freckled are not so strongly gene dependent as in delta. The third point is that delta resembles a virus in its (Burdette andYoon 1967, Yoon 1969) or viruses carried by other insects (Gershenson 1969) which induce mutations of Drosophila melanogaster.…”

Section: Discussionmentioning

confidence: 99%

EXTRACHROMOSOMAL ELEMENT DELTA IN <i>DROSOPHILA MELANOGASTER</i>

Minamori

1971

The Japanese journal of genetics

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“…mutagenesis in some instances (2,3). On considering the relationship between viral infection and chromosome disturbances in Blood samples from both patients with Down's syndrome and human cells, previous cytogenetic studies do not necessarily give controls were cultured for 72 hr, including a terminal incubation much information on this interaction.…”

Section: Speculationmentioning

confidence: 99%

Chromosome Damage in Down's Syndrome Induced by Chickenpox Infection

et al. 1976

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Pediat. R e s . 10: 189-192 (1976 Extract after chickenpox infection. Two groups of normal children were studied as controls, one group before chickenpox infection and one Chromosomes were studied in 74-hr lymphocyte cultures from group during and I and 3 months after infection. ~h~ ages and seven patients with Down's syndrome and from 12 he ma to logic all^ sexes ofchildren included i n study are in ~~b l 1 and karyotypically normal control subjects. Six were studied be-and 2, fore and six after chickenpox infection. In Down's syndrome, the number of breaks per cell was 0. and also significantly greater than the number of breaks, 0.046 * trisomy 21 who ranged from 2--6 years of age and from six control 0.023, observed in control children with chickenpox. Therefore, children with normal karyotypes and normal hematologic findings, chromosomes from patients with Down's syndrome were signifi-2-6 years of age. Chickenpox was diagnosed clinically from the cantly more sensitive to breakage after chickenpox infection than appearance on the skin and mucous membranes of successive crops those from control subjects. of typical vesicles which was generally accompanied by a mild The incidence of chromosome breaks in Down's syndrome 1 constitutional reaction. Children with atypical chickenpox were month after chickenpox infection fell to the level observed in the excluded from this study. Blood samples were collected 1-3 days preinfection range. The present results showed that the difference after onset of the specific rash, and subsequently 1 and 3 months between the observed and the expected values for breakage in special after infection. N o individual had received either x-rays for regions of chromosome was not significant, but that chromosome diagnosis or chloramphenicol therapy in the recent past. breakage was random.) Chickenpox Down's s y n d r o m e c h r o m o s o m e d a m a g e

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Mutations, Chromosomal Aberrations, and Tumors in Insects Treated with Oncogenic Virus

Cited by 31 publications

References 1 publication

Genome and stresses: Reactions against aggressions, behavior of transposable elements

Genome and stresses: Reactions against aggressions, behavior of transposable elements

EXTRACHROMOSOMAL ELEMENT DELTA IN <i>DROSOPHILA MELANOGASTER</i>

Chromosome Damage in Down's Syndrome Induced by Chickenpox Infection

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