2024
DOI: 10.1101/2024.07.17.603971
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Mutations in the riboflavin biosynthesis pathway confer resistance to furazolidone and abolish the synergistic interaction between furazolidone and vancomycin inEscherichia coli

Hannah Wykes,
Vuong Van Hung Le,
Jasna Rakonjac

Abstract: Antibiotic combinations are a promising strategy to counteract the global problem of increasing antibiotic resistance. We have previously demonstrated furazolidone-vancomycin synergy against Gram-negative pathogens. Here, we selectedEscherichia coliprogeny for growth on the furazolidone-vancomycin combination to which the parent was sensitive. We show that selected clones were associated with increased resistance to neither, only one of, or both furazolidone and vancomycin, but in all cases were associated wit… Show more

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