Mutations of p53 gene and their relation to disease progression in B- cell lymphoma

Ichikawa, Atsushi; Hotta, Tomomitsu; Takagi, Naofumi; Tsushita, Keitaro; Kinoshita, Tomohiro; Nagai, Hirokazu; Murakami, Yukihiro; Hayashi, Kiichiro; Saitô, Hitoshi

doi:10.1182/blood.v79.10.2701.bloodjournal79102701

Cited by 115 publications

(34 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study we used FISH to investigate the incidence of p53 deletions in 79 patients with NHL. We found that p53 deletion was an uncommon abnormality in patients with NHL; however, unlike previously published studies (Lo Coco et al, 1993;Sander et al, 1993;Ichikawa et al, 1992), we found no correlation between p53 deletions and poor prognosis.…”

contrasting

confidence: 99%

“…Because an intact p53 function is required for the cells to undergo apoptosis induced by radiation and chemotherapy, p53 alteration can mediate resistance to these treatment modalities (Chang et al, 1995). For patients with non-Hodgkin's lymphoma, p53 alterations have been reported to correlate with clinical tumour stage, disease progression and poor outcome (Lo Coco et al, 1993;Sander et al, 1994;Ichikawa et al, 1992).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Analysis of p53 gene deletions in patients with non‐Hodgkin's lymphoma by dual‐colour fluorescence in‐situ hybridization

Clodi¹,

Younes

Goodacre³

et al. 1997

Br J Haematol

View full text Add to dashboard Cite

The most common tumour suppressor gene altered in human cancers is p53, which is located on the short arm of chromosome 17. Structural abnormalities of the short arm and loss of chromosome 17 have been reported to confer resistance to chemotherapy in patients with non‐Hodgkin's lymphoma (NHL). Therefore we studied the incidence and prognostic value of p53 deletions in patients with NHL by fluorescence in‐situ hybridization using a 40 kb cosmid probe. Specimens obtained from 79 patients with NHL were studied. 46 patients were untreated, and 33 were previously treated. 40 tumours had indolent and 39 had aggressive histologies. p53 deletions were observed in 14 specimens (18%) in 32–90% of the cells. No statistically significant difference in the incidence of p53 deletion was observed between indolent and aggressive NHLs or between untreated and previously treated patients. However, p53 deletions were observed in three of four patients with transformed lymphoma. In the untreated patients, p53 deletion had no effect on response to therapy, time to treatment failure, or survival. We conclude that p53 deletions are uncommon in NHL, and may be frequent in patients with transformed lymphoma. In this study, p53 deletions did not influence treatment outcome or prognosis of NHL. Because monosomy 17 and 17p abnormalities have been reported to confer poor prognosis in NHL, other tumour suppressor genes on 17p should therefore be studied.

show abstract

contrasting

confidence: 99%

mentioning

confidence: 99%

Analysis of p53 gene deletions in patients with non‐Hodgkin's lymphoma by dual‐colour fluorescence in‐situ hybridization

Clodi¹,

Younes

Goodacre³

et al. 1997

Br J Haematol

View full text Add to dashboard Cite

show abstract

“…7 In the present series of NHL, exon 5 was the most common mutation site, accounting for seven of nine mutations (77%). In previous reports of NHL, either no predominant site for p53 mutation was apparent, 27,28 or there was a high prevalence in exons 6 and 7. 29,30 In the present series there were two cases (one DLBL and one ATL) that harbored double transversion mutations consisting of a missense mutation and a nonsense mutation.…”

Section: Discussionmentioning

confidence: 81%

Missense mutation with/without nonsense mutation of the p53 gene is associated with large cell morphology in human malignant lymphoma

Mitani

Kamata

Fujiwara

et al. 2007

Pathology International

View full text Add to dashboard Cite

Mutations in p53 gene exons 5-9 were studied in 44 non-Hodgkin's lymphomas (NHL) consisting of 35 B-NHL and 9 T-NHL. Missense mutations were found in two diffuse large B-cell lymphomas (DLBL) and one peripheral T-cell lymphoma (unspecified). Double transversion missense and nonsense mutations were detected in one DLBL and one adult T-cell leukemia/lymphoma. Silent mutations were found in two DLBL. Detailed histomorphological study showed that cases harboring p53 missense mutation with/without nonsense mutation tended to have larger nuclei with much more prominent nucleoli. Cytomorphometric analysis was therefore conducted by measuring the gross area of 100 lymphoma cell nuclei in 44 cases and the results were compared between lymphomas harboring p53 missense mutation with/without nonsense mutation and lymphomas harboring p53 silent mutation or lacking mutation. It was found that the lymphomas harboring p53 missense mutation with/without nonsense mutation had a highly significantly larger nuclear gross area than lymphomas with silent p53 mutation or lacking mutation (two-sample t-test, P < 0.00001; Exact Wilcoxon rank-sum test, P < 0.00001). This result suggests that p53 mutation might induce enlargement of neoplastic cell nuclei by some molecular mechanism.

show abstract

“…3,27,28 p53 gene mutations are considered as a pejorative finding in post-transplant LPD. 3,29 Chetty et al 30 report a marked expression of bcl-2 while p53 is downregulated in adult posttransplant LPDs with high-grade histology. For Chetty et al, these findings help to differentiate polymorphic LPD from high-grade NHL in which they found, as we did in our series, a marked expression of p53 protein.…”

Section: Discussionmentioning

confidence: 99%

Lymphoproliferative disorders in children with primary immunodeficiencies: immunological status may be more predictive of the outcome than other criteria

et al. 2001

View full text Add to dashboard Cite

This study documents the pleomorphism of LPDs in primary immunodeficiency compared to post-transplant children, even if some LPDs are similar in both groups (PLPDs). No criteria are useful enough to ascertain the diagnosis of malignancy in this series. Some molecular biological criteria help to predict the clinical outcome which, nevertheless, seems to depend more on the degree of immunosuppression and on T-lymphocyte presence and function.

show abstract

Mutations of p53 gene and their relation to disease progression in B- cell lymphoma

Cited by 115 publications

References 0 publications

Analysis of p53 gene deletions in patients with non‐Hodgkin's lymphoma by dual‐colour fluorescence in‐situ hybridization

Analysis of p53 gene deletions in patients with non‐Hodgkin's lymphoma by dual‐colour fluorescence in‐situ hybridization

Missense mutation with/without nonsense mutation of the p53 gene is associated with large cell morphology in human malignant lymphoma

Lymphoproliferative disorders in children with primary immunodeficiencies: immunological status may be more predictive of the outcome than other criteria

Contact Info

Product

Resources

About