Mutations of p53 gene exons 4-8 in human esophageal cancer

Abstract

Mutation of p53 gene in exon 4 may play an important role in development of esophageal cancer. The observation of p53 gene mutation in adjacent non-cancerous tissues suggests that p53 gene mutation may be an early event in esophageal carcinogenesis. Some clinical factors, including age, sex, pre-operation therapy and location of tumors, do not influence p53 gene mutation rates.

P53 Mutations in Advanced Cancers: Clinical Characteristics, Outcomes, and Correlation between Progression-Free Survival and Bevacizumab-Containing Therapy

“…Our analysis showed that p53 mutations occurred more frequently in Caucasian patients in contrast to previously reported data which showed that p53 mutation status did not differ between Caucasian and AfricanAmerican patients (18,19). However, the limited number of patients in our series precludes making definitive comparisons.…”

Molecular Analysis of the p53 Gene in Patients with Intestinal Metaplasia of the Cardia and Barrett's Esophagus: Characterization by Sequencing

“…This could be explained by the low number of samples. It has already been demonstrated that mutations in TP53 rarely happen outside exons 5 to 8 of the gene [3]. Our results show that except for one mutation (E8) 14483delG Deletion 2 Blood ---BE ---3 Blood Insertion BE ---13 Blood ---BE ---14 Blood ---IMC ---15 Blood ---BE ---16 Blood ---IMC ---Note.…”

“…Furthermore, due to the small number of cells that have molecular alterations at this stage, the results may be underestimated, especially due to the great quantity of inflammatory cells and stroma, which is a consequence of wild-type alleles coming from normal cells collected at the time of biopsy [3]. According to the IARC (International Agency for Research on Cancer), the prevalence of mutations of TP53 is 12.5% for normal tissues and about 17% for BE.…”

Analysis of R213R and 13494 g→a polymorphisms of the p53 gene in individuals with esophagitis, intestinal metaplasia of the cardia and Barrett’s Esophagus compared with a control group

“…1996 the association of the molecular findings with the histological type occurs upon development of the BE since the type I metaplasia (common in BE) would be more responsive to damage caused by GERD and therefore more prone to developing aneuploidies than the tissues analyzed in our study (Li et al. 2005). Without doubt, this could provide an explanation to the fact that our results do not differ from those in the control population, since the tissues assayed were in early stages of BE development.…”