Mutations of the peroxisome proliferator-activated receptor γ (PPARγ) gene in a Japanese population : the Pro12Ala mutation in PPARγ2 is associated with lower concentrations of serum total and non-HDL cholesterol

Association of Pro12Ala polymorphism in the peroxisome proliferator–activated receptor γ2 gene with small dense low-density lipoprotein in the general population

“…The most important findings were that Pro12Ala polymorphism in its homozygous and heterozygous forms may itself increase the area of sdLDL4-7 independent of potential confounding factors such as age, sex, BMI, habitual exercise, alcohol intake, and lipid concentration. The present finding that subjects with the X/Ala genotype had a lipid atherogenic profile is consistent with some previous results [8,9] but not all [3][4][5][6]. It has been proposed that the PPARγ2 gene is one of the mediators of gene-environmental interactions.…”

“…However, studies on the association between the Pro12Ala polymorphism and lipid profiles have been controversial. Several studies have shown the effect of Pro12Ala polymorphism on lower lipid and lipoprotein levels [3][4][5][6], but others have yielded inconsistent results [7][8][9].…”

Gender, Body Mass Index, and PPARγ Polymorphism Are Good Indicators in Hyperuricemia Prediction for Han Chinese

“…The results displayed that the sensitivity decreased to 63.9% and the 1-specificity increased from 16.3% to 23.9% (data not shown). Accordingly, PPARg gene owns potential capacity for the predisposition to hyperuricemia due to its association with xanthine oxidase/reductase activity (Cheung et al, 2007), obesity (Chen et al, 2009a), glucose (Ylonen et al, 2008;Ruchat et al, 2010), blood pressure (Halabi et al, 2008), and lipid (Iwata et al, 2001;Ylonen et al, 2008;Johansson et al, 2009) homeostasis. We supposed that PPARg gene may play a foundational role in hyperuricemia etiology rather than metabolic abnormality, dietary protein intake, and obesity, which were downstream of the physiological pathway regulated by PPARg gene.…”

“…The PPARg gene is associated with xanthine oxidase/ reductase activity (Cheung et al, 2007), glucose (Ylonen et al, 2008;Ruchat et al, 2010), blood pressure (Halabi et al, 2008), and lipid metabolism (Iwata et al, 2001;Ylonen et al, 2008;Johansson et al, 2009). We also have previously reported that polymorphisms of the PPARg gene were strongly associated with obesity in Han Chinese (Chen et al, 2009a).…”

PPARγ2Pro12Ala Polymorphism and Human Health

“…Ala12 allele is inversely associated with blood TAG concentrations in one report [54] while it has also been found to be associated with a trend of an increase in TAG and hyperlipidemia in another [152]. This variant has also been shown to be associated with lower levels of serum total and nonhigh-density lipoprotein (non-HDL)-cholesterol in a general population [153], lower low-density lipoprotein (LDL)-cholesterol in T2D patients [154], or higher levels of serum HDL-cholesterol in family-based or population-based studies [155, 156]. however, several studies also show an association of Ala12 allele with higher concentration of low-density lipoprotein (LDL)-cholesterol [68, 157] and lower HDL-cholesterol [70].…”