Mutilating hand syndrome in an infant with familial carpal tunnel syndrome

A novel NGFB point mutation: a phenotype study of heterozygous patients

“…A child with HSAN IV has been described with CTS. His relatives also had CTS and the authors suggested that the child may be homozygous, and that HSAN IV in the heterozygous form predisposes to familial CTS 17. The mechanism is still unclear.…”

Primary Familial Carpal Tunnel Syndrome with Long-term Followup: A Study of Two Families and Review of the Literature

“…This is especially important in children, who may not complain of symptoms but have electrodiagnostic evidence of nerve damage [1,4,8,9,33]. Patient #3's initially unilateral presentation, but ultimate need for contralateral CTR, illustrates how FCTS can progress to involve both upper extremities, increasing the risk for permanent nerve damage if not appropriately addressed.…”

“…Swoboda suggests that clinical examination and electrodiagnostic testing should also be carried out in parents and siblings of affected patients, regardless of whether signs and symptoms are present [9].…”

“…Phalen's test was positive at the most small FCTS case series have been published. However, essentially all of these studies lack outcome measures beyond five years postoperatively [2,4,[8][9][10][11][12]. In addition, there are few reports noting outcomes in children afflicted with this condition.…”

Missed Childhood-Onset Carpal Tunnel Syndrome Diagnosed as Chronic Pain: Case Report

“…In some cases, children present with automutilation as a result of median neuropathy. 7,8 In addition, nerve studies may be confounded in smaller hands because of the proximity of the placement of stimulation and recording electrodes. 9 Unlike adults, the only intervention shown to be effective in children is carpal tunnel decompression.…”