Mutilating/Resorptive Arthritis. A Study of 24 Patients in a Series of 360 Patients With Psoriatic Arthritis

Psoriatic Arthritis Mutilans: Case Series and Literature Review

“…In the largest series 3 , the AM was significantly associated with arthritis duration, involvement of distal phalanges, and reduced functional capacity. The prevalence (55%) of psoriatic nail involvement in AM did not differ from that of other psoriatic patients 3 . A study found that bone edema, erosion, and proliferation on magnetic resonance imaging (MRI) were significantly more severe in the patients with AM than in controls 4 .…”

“…Only studies in which clinical data of patients with AM were specifically reported were extracted. Full articles of all relevant studies were retrieved, and manual searches of reference lists from these articles were performed, identifying 14 suitable studies ( Figure 2) 3,4,5,6,7,8,9,10,11,12,13,14,15,16 . Including our series, a total of 120 patients with AM are described ( Table 1).…”

“…Much more effort is required to diagnose those patients whose PsA is progressing toward mutilation in an earlier stage. Development of AM has been associated with a longer arthritis duration, involvement of distal phalanges, and impaired functional capacity 3 , suggesting these patients should undergo tight disease control and therapy. Radiological assessment of joints may be useful for clinical management of PsA.…”

Psoriatic Arthritis Mutilans: Clinical and Radiographic Criteria. A Systematic Review

“…Citations were excluded if they were not related to the topic (n = 7375), reported patients with other rheumatic diseases (n = 47), did not report PAM as an outcome (n = 53), or were duplicate citations (n = 983). Of the 112 articles selected for full review, 58 were eligible for data abstraction 2,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64]…”

Disease activity in and quality of life of patients with psoriatic arthritis mutilans: the Nordic PAM Study

“…As the reference group had a significantly shorter disease duration than the PAM group, it could be surmised that the real difference in function between PAM and the reference group may be even more pronounced than observed herein. RodriguezMoreno et al reported reduced functional capacity in PAM, estimated by HAQ, and functional status according to American College of Rheumatology criteria, being affected primarily by disease duration and distal interphalangeal involvement (36).…”