Mutltifaceted biological roles of leptin

Charchour, Rim; Dufour‐Rainfray, Diane; Morineau, Gilles; Vatier, Camille; Fellahi, Soraya; Vigouroux, Corinne; Genoux, Annelise; Capeau, Jacqueline; Collet, Christine; Cuerq, Charlotte; Bastard, Jean‐Philippe

doi:10.1684/abc.2020.1560

Cited by 5 publications

(4 citation statements)

References 76 publications

(95 reference statements)

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“…Cross-sectional and prospective studies have observed an association between leptin concentrations and MetS independent of obesity [38,39]. Leptin has different biological roles, including energy balance and endocrine function [40]. Studies have observed that a dysfunctional adipose tissue produces adipokines (e.g., adiponectin and leptin) in abnormal concentrations and is associated with cardiometabolic problems [37].…”

Section: Discussionmentioning

confidence: 99%

Micronutrients and Markers of Oxidative Stress and Inflammation Related to Cardiometabolic Health: Results from the EHES-LUX Study

et al. 2020

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Metabolic syndrome (MetS) characteristics include chronic inflammation and elevated oxidative stress. This study assessed associations between circulating concentrations of micronutrients/phytochemicals and inflammatory/oxidative stress markers with MetS and MetS components. Adults (N = 606) from the European Health Examination Survey in Luxembourg (2013–2015) were randomly selected. We performed a multivariable logistic regression model using the least absolute shrinkage and selection operator to identify MetS-associated variables. Participants with MetS had higher concentrations of C-reactive protein (CRP), 8-iso-prostaglandin F2α, leptin, insulin, and vitamins E/A, but lower concentrations of adiponectin, beta-carotene, and oxidized low-density lipoprotein. A one-unit increase in log-CRP was associated with 51% greater odds of MetS (OR = 1.51 (95% CI: 1.16, 1.98)). Adults with a one-unit increase in log-leptin were 3.1 times more likely to have MetS (3.10 (2.10, 4.72)). Women with a one-unit increase in vitamin A were associated with 3% increased odds of MetS (1.03 (1.01, 1.05)), while those with a one-unit increase in log-adiponectin were associated with 82% decreased odds (0.18 (0.07, 0.46)). Chronic inflammation best characterized adults with MetS, as CRP, adiponectin, and leptin were selected as the main MetS determinants. Micronutrients did not seem to affect MetS, except for vitamin A in women.

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Section: Discussionmentioning

confidence: 99%

Micronutrients and Markers of Oxidative Stress and Inflammation Related to Cardiometabolic Health: Results from the EHES-LUX Study

et al. 2020

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“…Leptin high concentration improves oxidative stress and inflammation and above all cardiovascular diseases [31]. Strong data have revealed that while functioning leptin improves fatty acid β-oxidation, prevents toxic lipid accumulation, and consequently expression of oxidative and inflammation mediators, elevated leptin levels caused abnormal lipid accumulation [32,33].…”

Section: Leptin: Biological Rolementioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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“…Leptin, a non-glycosylated hormone, is necessary for food intake, energy homeostasis, hormone synthesis, hematopoiesis, and immunity [ 39 , 40 ]. Many studies report that leptin participates in the pathophysiology of neurovascular disease, obesity, endocrine disease, metabolism-related disease, and cancer [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma

Luo

Tsai

Chiu

et al. 2022

IJMS

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Leptin is a crucial regulator of metabolism and energy homeostasis in mammals. Many studies have investigated the impacts of leptin on human cancers, such as proliferation and metastasis. However, the mechanisms underlying leptin-mediated regulation of lipid metabolism in nasopharyngeal carcinoma (NPC) remain incompletely understood. In the current study, leptin downregulation ameliorated lipid accumulation, triglyceride, and cholesterol levels. Mechanistically, diminished leptin by siRNA not only inhibited sterol regulatory element-binding protein 1 (SREBP1), a master regulator of lipid metabolism, at the mRNA and protein levels, but also reduced SREBP1 downstream target expressions, such as fatty acid synthase (FASN) and stearoyl-CoA desaturase-1 (SCD1), in NPC cells. In addition, leptin expression could modulate the promoter activity of SREBP1. We also found that pharmacological inhibition of poly-ADP ribose polymerase-γ (PPAR-γ) resulted in increased SREBP1 expression in leptin-depleted NPC cells. Functionally, SREBP1 overexpression overcame the effects of leptin-silencing attenuated triglyceride level, cholesterol level and cell survival in NPC cells. Taken together, our results demonstrate that leptin is an important regulator of lipid metabolism in NPC cells and might could be a potential therapeutic target for treatment of NPC patients.

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Mutltifaceted biological roles of leptin

Cited by 5 publications

References 76 publications

Micronutrients and Markers of Oxidative Stress and Inflammation Related to Cardiometabolic Health: Results from the EHES-LUX Study

Micronutrients and Markers of Oxidative Stress and Inflammation Related to Cardiometabolic Health: Results from the EHES-LUX Study

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma

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