Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema

A Combined Omics Approach to Generate the Surface Atlas of Human Naive CD4+ T Cells during Early T-Cell Receptor Activation

“…On the other hand the bioinformatics approach used for the identification of cell surface proteins (including the putative data set) presents a great assembly of further genes (n ϭ 1074) potentially coding for cell surface proteins, which have to be experimentally validated on a proteomic level on the surface of human naive CD4 ϩ T cells. The fact that these surface membrane protein coding genes, which were identified by the bioinformatics analysis, were not detected by the two proteomic approaches might be explained by (1) not all genes present on the RNA level are translated into proteins, (2) proteins are subjected to post-translational modifications, translocation, and degradation, and (3) not all of the genes code for proteins containing a glycosylation site. A potential N-glycosylation site was proposed for 69% of the genes coding for cell surface proteins by the UniProtKB database (supplemental Table S3).…”

“…The differentiation process of naive T cells is tightly regulated in healthy individuals. Pathology develops under dysregulated effector responses such as overshooting responses leading to impaired tolerance (2) or ineffective control of infections (3). Naive T cells are defined by CD45RA expression and they are early cellular targets of immune modulation regarding the differentiation process and the development of long lasting, sustainable therapeutic strategies.…”

NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management

“…Based on our previous findings that patients affected by both psoriasis and eczema at the same time are a unique model to study different inflammatory responses in the same organ [6], we recently performed intraindividual genome expression analysis of biopsy specimens from patients of this rare cohort [7]. In brief, we found that psoriasis-specific genes related to epidermal differentiation, Th17 responses as well as glucose and lipid metabolism, whereas eczema was characterized by genes related to epidermal barrier and Th2-related cytokines.…”

The role of IL-4 in psoriasis

“…JAK inhibitors targeting the downstream signaling molecules of the IL-4R are also under clinical investigation for the treatment of atopic dermatitis. Thus, IL-4 is one key cytokine discriminating between atopic and psoriatic skin inflammation [13].…”