2022
DOI: 10.3389/fnbeh.2022.877256
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Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids

Abstract: BackgroundSteroids are lipid hormones that reach bodily tissues through the systemic circulation, and play a major role in reproduction, metabolism, and homeostasis. All of these functions and steroids themselves are under the regulation of the circadian timing system (CTS) and its cellular/molecular underpinnings. In health, cells throughout the body coordinate their daily activities to optimize responses to signals from the CTS and steroids. Misalignment of responses to these signals produces dysfunction and… Show more

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Cited by 8 publications
(7 citation statements)
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“…There is a vast literature from our lab and many others on the body-wide effects of each of these systems. [8][9][10][11]…”
Section: Why Do We Care?mentioning
confidence: 99%
See 1 more Smart Citation
“…There is a vast literature from our lab and many others on the body-wide effects of each of these systems. [8][9][10][11]…”
Section: Why Do We Care?mentioning
confidence: 99%
“…In that case, the signal from the SCN reaches a target in the OVLT, which in turn communicates throughout the brain via the cerebrospinal fluid. There is a vast literature from our lab and many others on the body‐wide effects of each of these systems 8–11 …”
Section: Introductionmentioning
confidence: 99%
“…Within rodents, androgen receptors are localized to the core region of the SCN and are sensitive to light stimulation ( Karatsoreos et al, 2007 ). Unlike androgen receptors, estrogen receptors are expressed in both the shell and core of the SCN, with one type of receptor, estrogen receptor-β being expressed more frequently than estrogen receptor-α (for review see Hatcher et al, 2020 ; Yao and Silver, 2022 ). Progestin receptors are also present in the SCN, but very little has been characterized about their localization ( Kruijver and Swaab, 2002 ).…”
Section: Defining Sex Hormones and Their Mode Of Action In The Scnmentioning
confidence: 99%
“…Brain and muscle Arnt-like protein-1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) are the key transcriptional activators of the mammalian clock (Drosophila homologues are dCYCLE and dCLOCK (dCLK)), and as heterodimers, they drive the expression of thousands of clock-controlled genes including genes that encode their own transcriptional repressors, PERIOD1-3 (PER1-3) and CRYP-TOCHROME1-2 (CRY1-2) (dPER and dTIMELESS (dTIM) in Drosophila) (figure 3). The molecular oscillator is critical for generating daily rhythmicity of gene expression that manifest into a range of rhythmic biological processes (reviewed in [1][2][3][4][5][6][7][8][9][10]). PTMs, especially phosphorylation, have been established as essential mechanisms for maintaining the pace of the molecular oscillator [174][175][176].…”
Section: Regulation Of Clock Proteins Within the Core Molecular Oscil...mentioning
confidence: 99%
“…In coordination with processes that are regulated by posttranscriptional mechanisms, clock-regulated rhythmic gene expression programs that are often tissue-and cell-specific produce daily rhythms in clock outputs. The outputs of animal circadian clocks are all-encompassing and include rhythmic processes such as sleep-wake cycles, feeding-fasting cycles, metabolism, hormone production and secretion, immune response, neuronal excitability and even permeability of the blood-brain barrier [3][4][5][6][7][8][9][10]. There is growing evidence that some clock outputs are themselves zeitgebers (i.e.…”
Section: Introductionmentioning
confidence: 99%