Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo

Kan, Yue-Yi; Song, Min Ho; Cui, Xihe; Yang, Qing; Zang, Yuan-Long; Li, Qi; Li, Yujie; Cai, Wei; Chen, Ying; Weng, Xiaogang; Wang, Yajie; Zhu, Xiaoxin

doi:10.1016/j.phymed.2021.153834

Cited by 10 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 Some small-molecule compounds targeting TNF receptors and ligands have been established based on their therapeutic effects against NSCLC. 27,28 Some representative com- the extrinsic apoptotic pathway in A549 cells. 30 A novel synthetic analogue of chrysin, AFMC (5-allyl-7-gen-difluoromethoxychrysi n) (13), caused 30% of A549 cells to undergo apoptosis when ad-ministeredataconcentrationof30 μM.…”

Section: Targeting Tnf Receptors and Ligandsmentioning

confidence: 99%

“…The apoptotic signaling pathway is blocked by death receptors when TNF ligands (such as FasL, TNF‐α, and TRAIL) bind to cognate receptors (such as Fas, TNFR1, and DR4/5) 26 . Some small‐molecule compounds targeting TNF receptors and ligands have been established based on their therapeutic effects against NSCLC 27,28 . Some representative compounds and the underlying pharmacological mechanisms of their actions are shown in Figure 2.…”

Section: Small‐molecule Compounds Targeting Apoptosis Factors For The...mentioning

confidence: 99%

“…The 6-amide group and HBD inhibited cancer cell growth, and later, a series of purine compounds containing a 6-hydroxamate or 6-amidoxime group were designed. Among these compounds, Compounds 17(27) and 19a(28) showed high antiproliferative ability in NSCLC cells (IC 50 = 0.37 ± 0.003 μM and 0.39 ± 0.01 μM, respectively). Both compounds induced apoptosis in A549 cells by promoting microtubule fragmentation and activation of the p53 signaling pathway.Invivoexperimentsrevealedthatthetumorvolume31 daysafter administration of 6 mg/kg Compounds 17 and 19a in mice wasreduced by 50% and 62.5%, respectively, while the mouse body weight remained stable, indicating that Compounds 17 and 19a induced low biotoxicity and showed good anticancer activity; therefore, they are expected to be candidates for the treatment of NSCLC 71.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy

Li,

Wang,

et al. 2023

Immunological Reviews

View full text Add to dashboard Cite

SummaryNon‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a very poor prognosis and a very low chance of survival. Human cancers are closely linked to regulated cell death (RCD), such as apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis. Currently, small‐molecule compounds targeting various types of RCD have shown potential as anticancer treatments. Moreover, RCD appears to be a specific part of the antitumor immune response; hence, the combination of RCD and immunotherapy might increase the inhibitory effect of therapy on tumor growth. In this review, we summarize small‐molecule compounds used for the treatment of NSCLC by focusing on RCD and pharmacological systems. In addition, we describe the current research status of an immunotherapy combined with an RCD‐based regimen for NSCLC, providing new ideas for targeting RCD pathways in combination with immunotherapy for patients with NSCLC in the future.

show abstract

Section: Targeting Tnf Receptors and Ligandsmentioning

confidence: 99%

Section: Small‐molecule Compounds Targeting Apoptosis Factors For The...mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy

Li,

Wang,

et al. 2023

Immunological Reviews

View full text Add to dashboard Cite

show abstract

“…During the COVID-19 pandemic, it was revealed that traditional Chinese medicine (TCM), such as Jinhua Qinggan granules and Lianhua Qingwen capsules, had a decisive role in the clinical treatment of COVID-19 by targeting ACE (5). Furthermore, a large number of studies have demonstrated that TCM serves an important role in the treatment of cancer, including colorectal cancer (6), breast cancer (7), hepatocellular carcinoma (8), lung cancer (9) and EC (10)(11)(12). Notably, the active ingredients of TCM are thought to inhibit cancer progression by regulating certain genes or signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

4‑Methoxydalbergione inhibits esophageal carcinoma cell proliferation and migration by inactivating NF‑κB

Xiao

Liu

et al. 2023

Oncol Rep

View full text Add to dashboard Cite

4-Methoxydalbergione (4-MD) can inhibit the progression of certain types of cancer; however, its effects on esophageal cancer (EC) remain unclear. The present study aimed to investigate the inhibitory effect of 4-MD on EC and its molecular mechanism. ECA-109 and KYSE-105 cells were treated with or without lipopolysaccharide (LPS) and 4-MD. Cell Counting Kit-8 and colony formation assays were used to analyze cell proliferation. Wound healing assay was performed to evaluate cell migration. ELISA and western blotting were performed to measure the expression levels of NF-κB and inflammatory cytokines. In cells treated with 4-MD, proliferation and migration were significantly inhibited, the levels of inflammatory cytokines were downregulated and the NF-κB signaling pathway was inactivated. Notably, proliferation, migration, inflammation and NF-κB were promoted by LPS, whereas 4-MD reversed the increases induced by LPS in EC cells. In conclusion, 4-MD may attenuate the proliferation and migration of EC cells by inactivating the NF-κB signaling pathway.

show abstract

Porphyromonas gingivalis-induced autophagy exacerbates abnormal lung homeostasis: An in vivo and in vitro study

Zhao,

Li,

et al. 2025

Archives of Oral Biology

View full text Add to dashboard Cite

Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo

Cited by 10 publications

References 37 publications

Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy

Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy

4‑Methoxydalbergione inhibits esophageal carcinoma cell proliferation and migration by inactivating NF‑κB

Porphyromonas gingivalis-induced autophagy exacerbates abnormal lung homeostasis: An in vivo and in vitro study

Contact Info

Product

Resources

About