Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study

Abstract

The mechanisms involved in the chronic hepatitis C progression are incompletely understood. The aim was to analyze the association between 2′5′oligoadenylate synthetase 1,2 and 3 (OAS1-3) and myxovirus resistance proteins 1 (Mx1) polymorphisms and severity of liver disease in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. We performed a cross-sectional study in 219 patients that underwent a liver biopsy. DNA genotyping for Mx1 (rs469390), OAS1 (rs2285934), OAS2 (rs1293762) and OAS3 (rs2010604) was performed by using GoldenGate assay. The outcome variables ion liver biopsy were: (i) significant fibrosis (F ≥ 2); (ii) moderate activity grade (A ≥ 2). Additive model of inheritance for genetic association test was used. The likelihood of having significant fibrosis (F ≥ 2) was lower in patients carrying OAS2 rs1293762 A allele [adjusted odds ratio (aOR) = 0.51; p = 0.040]. Besides, the likelihood of having moderate activity grade (A ≥ 2) was higher in patients carrying Mx1 rs464397 C allele (aOR = 1.63; p = 0.028) and Mx1 rs469390 G allele (aOR = 1.97; p = 0.005), while it was lower in patients carrying OAS1 rs2285934 A allele (aOR = 0.64; p = 0.039) and OAS2 rs1293762 A allele (aOR = 0.41; p = 0.009). In conclusion, Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis.

Mapping Viral Susceptibility Loci in Mice

“…Since the identification of the Flv gene, some human and equine OAS1 alleles have been linked to increased susceptibility to WNV-induced encephalitis (102), demonstrating the importance of Oas1 in the control of WNV infection across multiple species. Alleles of human Oas1 with reduced activity against WNV were also found to have a reduced ability to inhibit HCV replication and are indicators of disease progression in HCV-infected patients (103)(104)(105).…”

Hepatitis C Virus Seroprevalence and Associated Risk Factors Among Male Drug Injectors in Kermanshah, Iran

“…Previous research has also identified history of imprisonment as one of the major risk factors for HCV infection in Iran and around the world (15,16,33,34). Many PWID with a history of imprisonment have poor health.…”

“…The prevalence of HCV infection in PWID ranges from 20% to 90% in different studies (5,(9)(10)(11)(12)(13)(14)(15)(16)(17). High-risk injection behaviors are the leading cause of HCV infection among PWID (18).…”

“…Other identified risk factors for HCV in PWID include history of imprisonment (13,15,16), drug injection more than the daily frequency (29,30), history of tattooing (15), and duration of injecting drug use (13). However, there is no recent information on HCV prevalence in PWID in Kermanshah, Iran.…”

Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of Chronic Kidney Disease

“…Besides, OAS1 was found to have the most links with other nodes in the glomerular PIN. Early studies have shown that OAS1 is associated with hepatitis C virus infection, multiple sclerosis, and type 1 diabetes [29-31]. However, the relationship between OAS1 and CKD remains to be established.…”