In recent years, advancements in the Internet of Things (IoT), manufacturing processes, and material synthesis technologies have positioned flexible sensors as critical components in wearable devices. These developments are propelling wearable technologies based on flexible sensors towards higher intelligence, convenience, superior performance, and biocompatibility. Recently, two-dimensional nanomaterials known as MXenes have garnered extensive attention due to their excellent mechanical properties, outstanding electrical conductivity, large specific surface area, and abundant surface functional groups. These notable attributes confer significant potential on MXenes for applications in strain sensing, pressure measurement, gas detection, etc. Furthermore, polymer substrates such as polydimethylsiloxane (PDMS), polyurethane (PU), and thermoplastic polyurethane (TPU) are extensively utilized as support materials for MXene and its composites due to their light weight, flexibility, and ease of processing, thereby enhancing the overall performance and wearability of the sensors. This paper reviews the latest advancements in MXene and its composites within the domains of strain sensors, pressure sensors, and gas sensors. We present numerous recent case studies of MXene composite material-based wearable sensors and discuss the optimization of materials and structures for MXene composite material-based wearable sensors, offering strategies and methods to enhance the development of MXene composite material-based wearable sensors. Finally, we summarize the current progress of MXene wearable sensors and project future trends and analyses.