MXenes as theranostics: Diagnosis and therapy including in vitro and in vivo applications

Aslam, Maira; Ahmad, Tahleel; Manzoor, Muhammad Husnain; Laiba,; Verpoort, Francis

doi:10.1016/j.apmt.2023.102002

Cited by 4 publications

(2 citation statements)

References 227 publications

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“…Polyoxometalate as functionalizing agent for Tantalum carbide was studied by L Zong et al, 2018 for theranostic application. MXene Functionalization with imaging agents or contrast agents enables real-time monitoring of drug distribution and therapeutic response, facilitating personalized medicine and treatment optimization ( Sivasankarapillai et al, 2020 ; Aslam et al, 2023 ; Nikazar, Mofidi, and Mortazavi, 2023 ).…”

Section: Biomedical Applicationmentioning

confidence: 99%

“…MXene nanosheets can be functionalized with imaging agents such as fluorophores, magnetic nanoparticles, or radioisotopes to enhance contrast in various imaging modalities including optical imaging, MRI, and nuclear imaging techniques (e.g., positron emission tomography (PET) or single-photon emission computed tomography (SPECT)). The integration of MXenes into polymer matrices ensures stability and biocompatibility of the contrast agents, enabling their use in vivo for non-invasive imaging ( Aslam et al, 2023 ). Ta 4 C 3 -IONP-SP nanocomposites represent a case employed in MRI applications (Z.…”

Section: Biomedical Applicationmentioning

confidence: 99%

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MXenes-polymer nanocomposites for biomedical applications: fundamentals and future perspectives

Parajuli

2024

Front. Chem.

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The article discusses the promising synergy between MXenes and polymers in developing advanced nanocomposites with diverse applications in biomedicine domains. MXenes, possessing exceptional properties, are integrated into polymer matrices through various synthesis and fabrication methods. These nanocomposites find applications in drug delivery, imaging, diagnostics, and environmental remediation. They offer improved therapeutic efficacy and reduced side effects in drug delivery, enhanced sensitivity and specificity in imaging and diagnostics, and effectiveness in water purification and pollutant removal. The perspective also addresses challenges like biocompatibility and toxicity, while suggesting future research directions. In totality, it highlights the transformative potential of MXenes-polymer nanocomposites in addressing critical issues across various fields.

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Section: Biomedical Applicationmentioning

confidence: 99%

Section: Biomedical Applicationmentioning

confidence: 99%

MXenes-polymer nanocomposites for biomedical applications: fundamentals and future perspectives

Parajuli

2024

Front. Chem.

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Soft, Multifunctional MXene-Coated Fiber Microelectrodes for Biointerfacing

Bi,

Garg,

Noriega

et al. 2024

ACS Nano

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Flexible fiber-based microelectrodes allow safe and chronic investigation and modulation of electrically active cells and tissues. Compared to planar electrodes, they enhance targeting precision while minimizing side effects from the device-tissue mechanical mismatch. However, the current manufacturing methods face scalability, reproducibility, and handling challenges, hindering large-scale deployment. Furthermore, only a few designs can record electrical and biochemical signals necessary for understanding and interacting with complex biological systems. In this study, we present a method that utilizes the electrical conductivity and easy processability of MXenes, a diverse family of two-dimensional nanomaterials, to apply a thin layer of MXene coating continuously to commercial nylon filaments (30–300 μm in diameter) at a rapid speed (up to 15 mm/s), achieving a linear resistance below 10 Ω/cm. The MXene-coated filaments are then batch-processed into free-standing fiber microelectrodes with excellent flexibility, durability, and consistent performance even when knotted. We demonstrate the electrochemical properties of these fiber electrodes and their hydrogen peroxide (H2O2) sensing capability and showcase their applications in vivo (rodent) and ex vivo (bladder tissue). This scalable process fabricates high-performance microfiber electrodes that can be easily customized and deployed in diverse bioelectronic monitoring and stimulation studies, contributing to a deeper understanding of health and disease.

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