My memories are important to me: Changes in autobiographical memory in amyotrophic lateral sclerosis.

Hsieh, Sharpley; Irish, Muireann; Foxe, David; Caga, Jashelle; Devenney, Emma; Hodges, John R.; Piguet, Olivier; Kiernan, Matthew C.

doi:10.1037/neu0000291

Cited by 6 publications

(4 citation statements)

References 76 publications

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“…Memory profile in ALS varies widely among studies from no deficits (Hsieh et al, 2016) to deficits even in short-term delays (Massman et al, 1996). This large variation suggests that some ALS patients might present marked EM impairment.…”

Section: Discussionmentioning

confidence: 99%

Papez Circuit Gray Matter and Episodic Memory in Amyotrophic Lateral Sclerosis and Behavioural Variant Frontotemporal Dementia

Bueno

Souza

Pinaya

et al. 2020

Brain Imaging and Behavior

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Amyotrophic lateral sclerosis and behavioural variant frontotemporal dementia are two different diseases recognized to overlap at clinical, pathological and genetic characteristics. Both conditions are traditionally known for relative sparing of episodic memory. However, recent studies have disputed that with the report of patients presenting with marked episodic memory impairment. Besides that, structural and functional changes in temporal lobe regions responsible for episodic memory processing are often detected in neuroimaging studies of both conditions. In this study, we investigated the gray matter features associated with the Papez circuit in amyotrophic lateral sclerosis, behavioural variant frontotemporal dementia and healthy controls to further explore similarities and differences between the two conditions. Our non-demented amyotrophic lateral sclerosis patients showed no episodic memory deficits measured by a short-term delayed recall test while no changes in gray matter of the Papez circuit were found. Compared with the amyotrophic lateral sclerosis group, the behavioural variant frontotemporal dementia group had lower performance on the short-term delayed recall test and marked atrophy in gray matter of the Papez circuit. Bilateral atrophy of entorhinal cortex and mammillary bodies distinguished behavioural variant frontotemporal dementia from amyotrophic lateral sclerosis patients as well as atrophy in left cingulate, left hippocampus and right parahippocampal gyrus. Taken together, our results suggest that sub-regions of the Papez circuit could be differently affected in amyotrophic lateral sclerosis and behavioural variant frontotemporal dementia.

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Section: Discussionmentioning

confidence: 99%

Papez Circuit Gray Matter and Episodic Memory in Amyotrophic Lateral Sclerosis and Behavioural Variant Frontotemporal Dementia

Bueno

Souza

Pinaya

et al. 2020

Brain Imaging and Behavior

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“…Following inconsistent initial reports, memory dysfunction in ALS has received increasing attention recently ( 7 , 64 ). While autobiographic memory seems to be preserved in ALS ( 65 ), semantic memory is often affected ( 66 ). Episodic memory is the most commonly evaluated memory domain in ALS, typically tested by list-learning tests, associate-learning tests, prose memory, as well as visual memory tests ( 7 ).…”

Section: Cognitive Dysfunctionmentioning

confidence: 99%

Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis

et al. 2018

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Amyotrophic lateral sclerosis (ALS) is now universally recognized as a complex multisystem disorder with considerable extra-motor involvement. The neuropsychological manifestations of frontotemporal, parietal, and basal ganglia involvement in ALS have important implications for compliance with assistive devices, survival, participation in clinical trials, caregiver burden, and the management of individual care needs. Recent advances in neuroimaging have been instrumental in characterizing the biological substrate of heterogeneous cognitive and behavioral deficits in ALS. In this review we discuss the clinical and radiological aspects of cognitive and behavioral impairment in ALS focusing on the recognition, assessment, and monitoring of these symptoms.

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“…The evidence reviewed here converges to suggest that impoverished retrieval of the personal past may form a transdiagnostic feature across neurodegenerative disorders, affecting not only the ability to recount ABM narratives in rich contextual detail but stripping the experience of its formerly evocative qualities. Importantly, while this review has focused on Alzheimer's disease and frontotemporal dementia syndromes, mounting research suggests that ABM impairments extend to other neurodegenerative disorders not traditionally classified as amnestic, such as Huntington's disease (Carmichael, Irish, Glikmann‐Johnston, Singh, & Stout, 2019; Carmichael, Irish, Glikmann‐Johnston, & Stout, 2019), Parkinson's disease (Smith et al, 2010) and Motor Neuron disease (Hsieh et al, 2016). Findings of severe ABM impairments in such nonamnestic syndromes impresses the need to reconsider current diagnostic frameworks and to rethink the status of memory impairment in these disorders.…”

Section: The Future Of Memory In Dementiamentioning

confidence: 99%

Autobiographical memory in dementia syndromes—An integrative review

Irish

2022

WIRES Cognitive Science

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Autobiographical memory represents a defining feature of human cognition, enabling us to vividly re‐experience salient events from the personal past. By mentally traversing different temporal contexts, humans can maintain an enduring sense of who we are as individuals, as well as envisaging our future goals and behaviors. The relative ease with which we engage in these endeavors, however, belies the remarkable complexity of the autobiographical memory system. Dementia syndromes offer compelling insights into the cognitive neuroarchitecture of autobiographical memory in the face of progressive neural insult to large‐scale brain networks. Importantly, the atrophy profiles of many neurodegenerative disorders follow coordinated and predictable trajectories, affecting key regions implicated in episodic and semantic memory. A wealth of evidence suggests that autobiographical memory disruption is a transdiagnostic feature of dementia, yet this impairment takes many forms and arises due to differential neurocognitive disturbances. This review aims to provide a comprehensive overview of the literature on autobiographical memory in typical and atypical presentations of Alzheimer's disease, as well as younger‐onset dementia syndromes such as frontotemporal dementia and primary progressive aphasia. I will demonstrate how the systematic study of autobiographical memory across dementia syndromes can constrain and inform our fundamental understanding of memory function and, in turn, stimulate new directions in how we conceptualize and assess these cognitive capacities. Consideration will further be given to clinical implications of autobiographical memory dysfunction with a view to developing targeted interventions to better support the person living with dementia. This article is categorized under: Psychology > Memory Neuroscience > Clinical Neuroscience Psychology > Brain Function and Dysfunction

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My memories are important to me: Changes in autobiographical memory in amyotrophic lateral sclerosis.

Abstract: The preservation of ABM in ALS has clinical implications for the use of life review as a therapeutic tool in a multidisciplinary care setting. (PsycINFO Database Record

Cited by 6 publications

References 76 publications

Papez Circuit Gray Matter and Episodic Memory in Amyotrophic Lateral Sclerosis and Behavioural Variant Frontotemporal Dementia

Papez Circuit Gray Matter and Episodic Memory in Amyotrophic Lateral Sclerosis and Behavioural Variant Frontotemporal Dementia

Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis

Autobiographical memory in dementia syndromes—An integrative review

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