Myasthenia gravis: a changing pattern of incidence

Casetta, Ilaria; Groppo, Elisabetta; Gennaro, Riccardo De; Cesnik, Carlos E. S.; Piccolo, Laura; Volpato, Stefano; Granieri, Enrico

doi:10.1007/s00415-010-5651-z

Cited by 79 publications

(79 citation statements)

References 17 publications

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“…The MG incidence rates in our population tended to statistically significantly increase in both genders during the study period (y = 3.299 + 14.363x, p = 0.002). In accordance with these findings, an increasing MG incidence has been reported since the mid-1980s, mainly due to late-onset MG [3,4,7,8,9,10,11]. …”

Section: Discussionsupporting

confidence: 66%

“…These variations can be explained by the following differences: geography, ethnicity, diagnostic accuracy, registration, and therapeutic protocols. On the other hand, there is a strong suggestion for a trend towards rising prevalence and incidence over time [3,4,7,8,9,10,11]. Up to now, only a few studies have compared these parameters in the same region through a long period of time and using similar methodology.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological Study of Adult-Onset Myasthenia Gravis in the Area of Belgrade (Serbia) in the Period 1979–2008

Lavrnić¹,

Basta²,

Rakočević-Stojanović³

et al. 2013

Neuroepidemiology

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Background: The aim of this study was to analyze the prevalence and incidence of adult-onset myasthenia gravis (MG) in the Belgrade population from 1979 to 2008. Methods: Data on the number of MG patients and their basic demographic and clinical characteristics were collected from hospital records (1979–1992) and the Belgrade MG Registry (1993–2008). Incidence and prevalence were standardized by the direct method (using the world standard population). A time-trend analysis of MG incidence was performed using a linear regression model. Results: During the study period 562 cases (316 women, 246 men) were registered. On December 31st, 2008, the standardized prevalence (according to the world standard population) was 188.3/1,000,000 (women: 237.8/1,000,000; men: 139.4/1,000,000). The average annual standardized incidence rate was 13.3/1,000,000 (women: 14.1/1,000,000; men: 12.2/1,000,000). The incidence rates tended to increase significantly in both sexes during the study period (y = 3.299 + 14.363x, p = 0.002). Age-specific incidence rates for women demonstrated a bimodal pattern, with the first peak in the 20- to 29-year age group and the second one in the ≥70-year group. For both genders, an increase in age-specific incidence rates was registered for all age groups, although this was significant (p = 0.001) only for an MG onset of ≥60 years of age. Conclusions: The study confirms an increase in the incidence of MG in the area of Belgrade during the study period, especially for those with MG onset after 60 years of age.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Epidemiological Study of Adult-Onset Myasthenia Gravis in the Area of Belgrade (Serbia) in the Period 1979–2008

Lavrnić¹,

Basta²,

Rakočević-Stojanović³

et al. 2013

Neuroepidemiology

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“…Different epidemiological studies, especially in Europe, have estimated the incidence density (ID) to range between 1.7 and 21.3/1,000,000/person-year [5,6], however, data from regions such as Latin America are scarce.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Autoimmune Myasthenia Gravis in a Health Maintenance Organization in Buenos Aires, Argentina

Bettini¹,

Chaves²,

Cristiano³

et al. 2017

Neuroepidemiology

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Background: Different epidemiological studies, especially in Europe, have estimated the incidence density of myasthenia gravis (MG) to range between 1.7 and 21.3/1,000,000/person-year; however, data from regions such as Latin America are scarce. This study is aimed at estimating the incidence and prevalence of acquired MG in Buenos Aires, Argentina. Methods: The study population comprised of affiliates of the Italian Hospital Medical Care Program, a prepaid health maintenance organization located in Buenos Aires. The evaluation method for case detection included a retrospective search from January 1, 2006, through December 31, 2012. Results: Of the 60 cases identified, 36 (60%) were females. The median age at diagnosis was 69 years (IQR 51.5-79). The mean age at diagnosis was 63.3 years (SD ±20). A total of 28 patients (46.7%) had generalized MG and 32 had ocular MG (53.3%). Thirty five patients (58.3%) had acetylcholine receptor antibodies and 2 (3.3%) had muscle-specific receptor tyrosine kinase antibodies. The crude incidence density (ID) of MG was 61.33 per 1,000,000 person-years (95% CI 47.62-79.99). The adjusted ID for the Argentinean population was 38.8 per 1,000,000 person-years (95% CI 27.09-50.51) and for the Buenos Aires population was 47.49 (95% CI 34.73-60.25). Conclusions: The results obtained are similar to those published for other geographical areas.

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“…MG has a prevalence of 20-400 per million based on large population studies, and OM comprises approximately 20% of all cases (Somnier et al 1991;Phillips et al 1992;Christensen et al 1993;Phillips and Torner 1996;MacDonald et al 2000;Casetta et al 2010). The classic statement of the disease being of old men and young woman is true with an age distribution being bimodal with incidence peaks in the 20's for women and 40's for men (Phillips and Torner 1996;Grob 1999;Mantegazza et al 2003;Matsuda et al 2005).…”

Section: Epidemiologymentioning

confidence: 99%