Myasthenia Gravis: A Report of Two Cases with Necropsy Findings

Giordano, A. S.; Haymond, J. L.

doi:10.1093/ajcp/14.5.253

Cited by 34 publications

(20 citation statements)

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“…The heart is commonly affected in cases with MG and thymoma. Several reports have shown extensive myocardial necrosis with in flammatory reaction, resembling the changes in skeletal muscle, but presumably of greater clinical importance [10,14,19,20]. Autopsy in 2 of our cases revealed a similar myocardi tis.…”

Section: Discussionsupporting

confidence: 59%

Serological Detection of Thymoma in Myasthenia Gravis

Aarli

Thunold

1981

Eur Neurol

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A purified citric acid extract (CAE) was prepared from skeletal muscle and coated onto sheep red cells for use in an indirect hemagglutination test. Out of 64 MG sera examined, only 5 contained antibodies to the CAE. Radiological evidence of a thymoma was found in 1, but thymectomy revealed a lymphoepithelioma in all 5 patients. In 4 of the patients, the tumor was very small or medium-sized. None of the CAE-negative patients had clinical, radiological or other evidence of a thymoma. The test is therefore a supplementary diagnostic method for the detection of a thymoma at an early stage.

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Section: Discussionsupporting

confidence: 59%

Serological Detection of Thymoma in Myasthenia Gravis

Aarli

Thunold

1981

Eur Neurol

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“…This relation was strengthened by the recognition of histological similarities of the involved muscle tissue in myasthenia gravis and thyrotoxicosis (Weigert and Laquer, 1901 ;Dudgeon and Urquhart, 1926;Cohen and King, 1932). At necropsy Giordano and Haymond (1944) and Ringertz (1951) examined the thyroid gland in their cases of myasthenia gravis and reported that the histological changes were consistent with previous thyroid hyperplasia associated with thyrotoxicosis. Lymphoid follicles with germinal centres are seen in the thyroid gland in Hashimoto's disease (Greene, 1950) and also in the thymus of myasthenia gravis (Burnet, 1962), both of which are now believed to be autoimmune diseases (Roitt et al, 1956 ;Burnet, BRITISH MEDICAL JOURNAL 1962).…”

Section: Discussionmentioning

confidence: 96%

Relation Between Myasthenia Gravis and Thyroid Disease

Sahay¹,

Blendis²,

Greene³

1965

BMJ

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The relation between myasthenia gravis and thyroid disease remains unclarified. The association is thought to be uncommon, and it is generally believed that hyperthyroidism is far more commonly associated with myasthenia gravis than is hypothyroidism. However, no explanation has been offered to account for this difference. The association of myasthenia gravis and hyperthyroidism has been reported by many authors (

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“…Thymoma is a well‐known complication of MG and is present in 10–15% of all MG patients . However, myositis and myocarditis are uncommon complications of MG. To our knowledge, only 12 autopsy cases of MG with thymoma associated with polymyositis and myocarditis have been reported previously . Moreover, the occurrence of multinucleated giant cells, hereafter referred to as giant cells, has been described in the skeletal muscles and myocardium in six of these 12 cases .…”

Section: Introductionmentioning

confidence: 99%

Giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma

Kon

Mori²,

Tanji³

et al. 2012

Neuropathology

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We describe an unusual case of myasthenia gravis. Our patient had been diagnosed as having myasthenia gravis with thymoma at the age of 64 years, and died of acute respiratory failure at the age of 80 years. Post mortem examination revealed CD8-positive lymphocytic infiltration with numerous giant cells in the skeletal muscles and myocardium. Immunohistochemical and ultrastructural studies revealed that there were two types of giant cells: histiocytic and myocytic in origin. Furthermore, both types of giant cells were immunopositive for proteins implicated in the late endosome and lysosome-protease systems, suggesting that endocytosis may be the key mechanism in the formation of giant cells. The present case, together with a few similar cases reported previously, may represent a particular subset of polymyositis, that is, giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma.

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Myasthenia Gravis: A Report of Two Cases with Necropsy Findings

Cited by 34 publications

References 0 publications

Serological Detection of Thymoma in Myasthenia Gravis

Serological Detection of Thymoma in Myasthenia Gravis

Relation Between Myasthenia Gravis and Thyroid Disease

Giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma

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